Document Detail

Safety concerns regarding ephedrine-type alkaloid-containing dietary supplements.
MedLine Citation:
PMID:  15040625     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The U.S. Air Force has adopted a policy "strongly discourag(ing) the use of ... ephedra." However, the literature regarding this topic is limited and widely opinioned. In light of growing public and medical debate over the safety and efficacy of ephedrine-type alkaloid-containing dietary supplements, a review of the literature and assessment of the data were accomplished. METHODS: Studies regarding Ma Huang, ephedra, ephedrine-type alkaloids, ephedrine, and dietary supplements were reviewed (from databases Medline, HealthSTAR, CINAHL, Cochrane Clinical Trials Database). Food and Drug Administration and Government Accounting Office documents (including reports and interagency communications) were reviewed. RESULTS: Significant manufacturing quality control issues exist. Few studies support their efficacy or safety. Weight loss and athletic performance appear to be only modestly improved, for short durations, in the setting of large numbers of (some serious) adverse event reports. Studies examining over-the-counter use are minimal. CONCLUSIONS: The current U.S. Air Force policy strongly discouraging the use of ephedrine-type alkaloid-containing dietary supplements appears to be supported.
Shannon Corey Miller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Military medicine     Volume:  169     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-04-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
74MDOS/SGOHE, 4881 Sugar Maple Drive, Wright Patterson Air Force Base, Wright State University, Dayton, OH 45433, USA.
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MeSH Terms
Adrenergic Agents / adverse effects*,  pharmacology
Dietary Supplements*
Drug and Narcotic Control / legislation & jurisprudence*,  trends
Ephedra / chemistry
Ephedrine / adverse effects*,  pharmacology
Military Medicine / legislation & jurisprudence*
United States
United States Food and Drug Administration / standards
Reg. No./Substance:
0/Adrenergic Agents; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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