Document Detail


Safety of the blood supply in a rural area of China.
MedLine Citation:
PMID:  20104105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the sensitivity and specificity of tests for hepatitis B surface antigen (HbsAg), hepatitis C virus (HCV), and syphilis conducted by laboratories of 3 blood collection organizations in a rural area of China.
METHODS: From October to December 2003, 1068 samples were collected from blood donors presenting to the 3 collection centers. All samples were tested twice using 2 different test kits for HBsAg, HCV, and syphilis. An aliquot was sent to the China National Center for Clinical Laboratories to confirm the local test results. Sensitivities and specificities of the 3 local blood centers/banks were calculated using the results of the National Center for Clinical Laboratories as the gold standard.
RESULTS: The sensitivity of the 3 blood collection center/banks ranged from 0% to 63.2% for HBsAg. For HCV, the sensitivity was 0%, and for syphilis, ranged from 0% to 85.7%. There were no HBsAg positives in one of the blood center/banks, and no syphilis positives in the other. Thus, sensitivity could not be measured for these tests in these 2 facilities. Combining all 3 tests, the overall sensitivity was 55.6%. The specificity was 100%.
CONCLUSIONS: The sensitivity of the local laboratories was inadequate and could cause possible infection for an unacceptable number of blood recipients. Action needs to be taken to improve the quality of testing to ensure the safety of the rural blood supply.
Authors:
Shusen Liu; Priscilla Figueroa; Keming Rou; Zunyou Wu; Xi Chen; Roger Detels
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  53 Suppl 1     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-23     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S23-6     Citation Subset:  IM; X    
Affiliation:
National Center for AIDS/STD Control and Prevention, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Blood Donors*
Blood Transfusion / adverse effects*
China / epidemiology
Hepacivirus / isolation & purification*
Hepatitis B / epidemiology,  transmission
Hepatitis B Surface Antigens / blood*
Hepatitis C / epidemiology,  transmission
Humans
Laboratories / standards
Rural Population
Sensitivity and Specificity
Serologic Tests / standards
Syphilis / blood*,  epidemiology
Grant Support
ID/Acronym/Agency:
D43 TW000013/TW/FIC NIH HHS; D43 TW000013-17/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Hepatitis B Surface Antigens
Comments/Corrections

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