| Safety of bepridil: from review of the European data. | |
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MedLine Citation:
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PMID: 1553894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In France, bepridil has been available since 1981 for treatment of angina. Reports of arrhythmogenic effects (torsades de pointes) related to bepridil led to the assembly of a task force of physicians from France and the Netherlands. The task force found that the risk of torsades de pointes was indeed increased in elderly patients, especially women greater than 70 years old, as well as in those taking diuretics, which can precipitate hypokalemia. Postmarketing surveillance data developed from 1981 to 1989 have revealed 108 validated episodes of torsades de pointes in patients treated with bepridil. Improved patient selection has dramatically decreased the incidence of this complication. Several comparative clinical trials assessing the safety of bepridil have concluded that the drug may prolong the QT interval in certain patients; however, no occurrence of torsades de pointes was documented in these safety studies. The 9-year French experience suggests that bepridil is a safe and effective agent for treatment of angina pectoris in properly selected patients. |
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Authors:
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P Coumel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 69 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-04-27 Completed Date: 1992-04-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 75D-78D Citation Subset: AIM; IM |
Affiliation:
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Hospital Lariboisiere, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angina Pectoris / drug therapy* Bepridil / adverse effects* Clinical Trials as Topic Female France Humans Male Middle Aged Netherlands Product Surveillance, Postmarketing Torsades de Pointes / chemically induced* |
| Chemical | |
Reg. No./Substance:
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64706-54-3/Bepridil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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