| Safety of azamethiphos in eel, seabass and trout. | |
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MedLine Citation:
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PMID: 14643697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The safety of azamethiphos (AZA), an organophosphorous insecticide and the active ingredient of Salmosan, was evaluated in the European eel, seabass and rainbow trout. Fish were bathed in 0.1 ppm AZA for a period of 60, 120 or 240 min. After termination of each treatment fish were transferred to clean aquaria and randomly sampled over 21 days. Compared to controls, brain acetylcholinesterase (AChE) was inhibited up to 44, 56 and 62% in eels, seabass and trout, respectively, with the inhibition being significant for up to 4 days in eels and seabass and 7 days in trout. As result of the AChE depression, fish displayed motor hyperactivity and erratic jumping at the onset of treatment. Mortality was observed only in trout following exposure for 240 min. A variable correlation observed among species between the level of exposure, the reduced activity of brain AChE and the signs of toxicity suggest that brain AChE should be considered as an indicator of exposure rather than as an index of toxicity of AZA. The present data indicate that at the therapeutic dosage of 0.1 ppm AZA for 1h can be safely used in eels, seabass and trout. The extended treatment times up to 240 min were equally safe for eels and seabass but not for trout. |
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Authors:
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L Intorre; G Soldani; A M Cognetti-Varriale; G Monni; V Meucci; C Pretti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 49 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 171-6 Citation Subset: IM |
Affiliation:
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Section of Pharmacology and Toxicology, Department of Veterinary Clinics, University of Pisa, Viale Piagge 2, Pisa 56124, Italy. intorre@vet.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
/
analysis,
metabolism Acute Toxicity Tests Animals Bass / physiology* Brain / enzymology Cholinesterase Inhibitors / toxicity* Eels / physiology* Fishes Hyperkinesis / chemically induced Insecticides / toxicity* Oncorhynchus mykiss / physiology* Risk Assessment Thiophosphoric Acid Esters / administration & dosage, toxicity* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 0/Insecticides; 0/Thiophosphoric Acid Esters; 35575-96-3/azamethiphos; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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