Document Detail


Safety assessment of myristic acid as a food ingredient.
MedLine Citation:
PMID:  17141389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myristic acid is used in the food industry as a flavor ingredient. It is found widely distributed in fats throughout the plant and animal kingdom, including common human foodstuffs, such as nutmeg. Myristic acid (a 14-carbon, straight-chain saturated fatty acid) has been shown to have a low order of acute oral toxicity in rodents. It may be irritating in pure form to skin and eyes under exaggerated exposure conditions, but is not known or predicted to induce sensitization responses. Myristic acid did not induce a mutagenic response in either bacterial or mammalian systems in vitro. Relevant subchronic toxicity data are available on closely related fatty acid analogs. In particular, a NOEL of >6000mg/kg was reported for lauric acid (a 12-carbon, straight-chain saturated fatty acid) following dietary exposure to male rats for 18 weeks and a NOEL of >5000mg/kg was reported for palmitic acid (a 16-carbon, straight-chain saturated fatty acid) following dietary exposure to rats for 150 days. The data and information that are available indicate that at the current level of intake, food flavoring use of myristic acid does not pose a health risk to humans.
Authors:
George A Burdock; Ioana G Carabin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-10-24
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  45     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-12     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  517-29     Citation Subset:  IM    
Affiliation:
Burdock Group, Washington DC 20006, USA. gburdock@burdockgroup.com
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Flavoring Agents / toxicity*
Humans
Myristic Acid / administration & dosage,  pharmacokinetics,  toxicity*
Risk Assessment
Safety
Chemical
Reg. No./Substance:
0/Flavoring Agents; 544-63-8/Myristic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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