Document Detail


Safety assessment of kola nut extract as a food ingredient.
MedLine Citation:
PMID:  19394393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kola nut extract is used in the food industry as a flavoring ingredient. Kola nut extract is derived from the seeds of primarily two tropical Cola species (Cola nitida (Vent.) Schott et Endl. or Cola acuminata (Beauv.) Schott et Endl.) of the Family, Sterculiaceae. Present day consumption of kola nut extract is 0.69 mg/kg/day. Caffeine and theobromine are two important constituents of kola nuts. Although limited biological data are available for kola nut extract specifically, the published data of the major constituents of kola nuts suggest the pharmacological/toxicological properties of kola nut extract, parallel to those of a roughly equivalent dose of caffeine. Frank developmental/reproductive effects have not been reported and changes in offspring cannot be extrapolated to humans. A NOEL/NOAEL cannot be defined for repeated oral exposure to kola nut extract from available data. Notwithstanding the foregoing, U.S. consumers have a history of safe consumption of cola-type beverages containing kola nut extract that dates at least to the late 19th Century, with a significant global history of exposure to the intact kola nuts that date centuries longer.
Authors:
George A Burdock; Ioana G Carabin; Christine M Crincoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-24
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1725-32     Citation Subset:  IM    
Affiliation:
Burdock Group, 801 N. Orange Ave Suite 710, Orlando, FL 32829, USA. gburdock@burdockgroup.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cola / chemistry,  toxicity*
Food / toxicity*
Humans
Male
Mutagens / toxicity
Neurotoxins / toxicity
Nuts / chemistry
Plant Extracts / toxicity
Rats
Teratogens / toxicity
Chemical
Reg. No./Substance:
0/Mutagens; 0/Neurotoxins; 0/Plant Extracts; 0/Teratogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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