Document Detail


Safety assessment of inhaled xylitol in subjects with cystic fibrosis.
MedLine Citation:
PMID:  16781897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Xylitol is a 5-carbon sugar that can lower the airway surface salt concentration, thus enhancing innate immunity. We tested the safety and tolerability of aerosolized iso-osmotic xylitol in subjects with cystic fibrosis. METHODS: In this pilot study, 6 subjects with cystic fibrosis and an FEV1>60% predicted underwent a baseline spirometry followed by exposures to aerosolized saline (10 ml) and 5% xylitol (10 ml). Serum osmolarity and electrolytes were measured at baseline and after xylitol exposure. Spirometry, oxygen saturation and respiratory symptom questionnaire using visual analog scale were tested at baseline and after each exposure. Sputum for cytokine analysis was collected after saline and xylitol nebulizations. RESULTS: There was no change in FEV1 after xylitol exposure compared with baseline or normal saline exposure (p=0.19). Laboratory values and respiratory symptoms were not affected by xylitol inhalation. The mean IL-8 level in the sputum was similar with saline and xylitol exposures (3.5+/-0.5 vs. 3.5+/-0.6 ng/ml). CONCLUSIONS: A single dose inhalation of aerosolized iso-osmotic xylitol was well tolerated by subjects with cystic fibrosis. Future studies of long term safety are required.
Authors:
Lakshmi Durairaj; Janice Launspach; Janet L Watt; Zeinab Mohamad; Joel Kline; Joseph Zabner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-06-15
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  6     ISSN:  1569-1993     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Roy J. and Lucille A., Carver College of Medicine, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / administration & dosage,  adverse effects*
Administration, Inhalation
Adult
Animals
Cystic Fibrosis / drug therapy*
Female
Humans
Immunity, Innate / drug effects
Interleukin-8 / analysis
Male
Mice
Xylitol / administration & dosage,  adverse effects*
Grant Support
ID/Acronym/Agency:
HL61234-06/HL/NHLBI NIH HHS; K23 HL071246-01A1/HL/NHLBI NIH HHS; RR00059/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Interleukin-8; 87-99-0/Xylitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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