Document Detail


Safety assessment of Cry1Ab/Ac fusion protein.
MedLine Citation:
PMID:  19341779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cry1ab/ac gene was fused by both the cry1ab gene (GenBank Accession No. X54939) and the cry1ac gene (GenBank Accession No. Y09787), which was widely used in genetically modified (GM) rice, cotton, maize and so on. In order to support the safety assessment of GM food or feed products containing Cry1Ab/Ac protein, sufficient quantities of Cry1Ab/Ac protein were produced in Escherichia coli for in vitro evaluation and animal studies. The Cry1Ab/Ac protein does not possess the characteristics associated with food toxins or allergens, i.e., it has no sequence homology with any known allergens or toxins, and no N-glycosylation sites, can be rapidly degraded in gastric and intestinal fluids, and is devoid of adverse effects in mice by gavage at a high dose level of 5g (Cry1Ab/Ac protein)/kg body weight. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the Cry1Ab/Ac protein in human food or animal feed.
Authors:
Wentao Xu; Sishuo Cao; Xiaoyun He; Yunbo Luo; Xing Guo; Yanfang Yuan; Kunlun Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-31
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1459-65     Citation Subset:  IM    
Affiliation:
Laboratory of Food Safety and Molecular Biology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.
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MeSH Terms
Descriptor/Qualifier:
Allergens / analysis
Amino Acid Sequence
Animals
Bacterial Proteins / pharmacokinetics,  toxicity*
Blood Chemical Analysis
Drug Stability
Endotoxins / pharmacokinetics,  toxicity*
Escherichia coli / metabolism
Female
Glycosylation
Hemolysin Proteins / pharmacokinetics,  toxicity*
Hot Temperature
Hydrolysis
Insecticides / pharmacokinetics,  toxicity*
Male
Mice
Molecular Sequence Data
Organ Size / drug effects
Oryza sativa / metabolism
Plants, Genetically Modified / metabolism
Recombinant Fusion Proteins / pharmacokinetics,  toxicity
Chemical
Reg. No./Substance:
0/Allergens; 0/Bacterial Proteins; 0/Endotoxins; 0/Hemolysin Proteins; 0/Insecticides; 0/Recombinant Fusion Proteins; 0/insecticidal crystal protein, Bacillus Thuringiensis

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