| Safety assessment of Cry1Ab/Ac fusion protein. | |
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MedLine Citation:
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PMID: 19341779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cry1ab/ac gene was fused by both the cry1ab gene (GenBank Accession No. X54939) and the cry1ac gene (GenBank Accession No. Y09787), which was widely used in genetically modified (GM) rice, cotton, maize and so on. In order to support the safety assessment of GM food or feed products containing Cry1Ab/Ac protein, sufficient quantities of Cry1Ab/Ac protein were produced in Escherichia coli for in vitro evaluation and animal studies. The Cry1Ab/Ac protein does not possess the characteristics associated with food toxins or allergens, i.e., it has no sequence homology with any known allergens or toxins, and no N-glycosylation sites, can be rapidly degraded in gastric and intestinal fluids, and is devoid of adverse effects in mice by gavage at a high dose level of 5g (Cry1Ab/Ac protein)/kg body weight. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the Cry1Ab/Ac protein in human food or animal feed. |
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Authors:
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Wentao Xu; Sishuo Cao; Xiaoyun He; Yunbo Luo; Xing Guo; Yanfang Yuan; Kunlun Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-31 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 47 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1459-65 Citation Subset: IM |
Affiliation:
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Laboratory of Food Safety and Molecular Biology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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analysis Amino Acid Sequence Animals Bacterial Proteins / pharmacokinetics, toxicity* Blood Chemical Analysis Drug Stability Endotoxins / pharmacokinetics, toxicity* Escherichia coli / metabolism Female Glycosylation Hemolysin Proteins / pharmacokinetics, toxicity* Hot Temperature Hydrolysis Insecticides / pharmacokinetics, toxicity* Male Mice Molecular Sequence Data Organ Size / drug effects Oryza sativa / metabolism Plants, Genetically Modified / metabolism Recombinant Fusion Proteins / pharmacokinetics, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Bacterial Proteins; 0/Endotoxins; 0/Hemolysin Proteins; 0/Insecticides; 0/Recombinant Fusion Proteins; 0/insecticidal crystal protein, Bacillus Thuringiensis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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