Document Detail


Safety aspects of long-term antihypertensive therapy (10 years) with clonidine.
MedLine Citation:
PMID:  2455159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have treated 128 patients aged 40 +/- 9 years (60 males and 68 females), all with essential hypertension (W.H.O. I and II), over a period of 10 yr. The treatment was performed with clonidine at a dose that ranged from 0.150 to 1,200 mg (twice daily). Forty-two patients also received a diuretic (HCTZ 25 mg daily). Mean blood pressure decreased significantly from 169 +/- 10 mm Hg systolic, 107 +/- 3 diastolic to 145 +/- 6 mm Hg (p less than 0.001) 90 +/- 3 mm Hg diastolic (p less than 0.001). Side effects occurred during the first month. These were drowsiness 28%, dry mouth 35%, constipation 13%, dizziness 9%, postural hypotension 2%, and male impotence 3.3% (2/60). Side effects still present after 120 months of treatment were drowsiness 11.7%, dry mouth 26.6%, constipation 14.1%, dizziness 4.7%, and male impotence 1.7% (1/59). The number of patients who discontinued treatment resulting from side effects were 3.34%, all of them within the first 6 months. There were no changes in renal or liver function or in serum electrolytes or lipids. Retinopathy improved in most patients. Electrocardiogram (ECG) improved in 45 patients with LVH. It is concluded that clonidine provided sustained blood pressure control with minimum side effects during 10-year therapy for hypertension.
Authors:
L Ferder; F Inserra; F Medina
Related Documents :
7983959 - Clinical trials with ambulatory blood pressure monitoring: fewer patients needed? syst-...
19397219 - Irbesartan/hydrochlorothiazide for the treatment of isolated systolic hypertension: a s...
16492489 - Evaluation and treatment of patients with severely elevated blood pressure in academic ...
94639 - Effects of prazosin in the control of blood pressure in hypertensive dialysis patients.
8227469 - Assessment of blood pressure during treatment with naproxen or ibuprofen in hypertensiv...
24306239 - Reversal by pressure of seed germination promoted by anesthetics.
2400079 - A disposable blood pressure cuff. an assessment of its accuracy.
10201049 - Benefit of in-phase chest wall vibration on the pulmonary hemodynamics in patients with...
7522549 - The dehydrating function of the descending colon in relationship to crypt function.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 12     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S104-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology Faculty of Medicine, University of Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Cardiomegaly / etiology
Cholesterol / blood
Clonidine / adverse effects*,  therapeutic use
Drug Therapy, Combination
Electrocardiography
Female
Follow-Up Studies
Humans
Hydrochlorothiazide / therapeutic use
Hypertension / complications,  drug therapy*,  physiopathology
Male
Middle Aged
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Triglycerides; 4205-90-7/Clonidine; 57-88-5/Cholesterol; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of pharmacokinetics and pharmacodynamics of adrenoceptor agonists and antagonists as anti...
Next Document:  Relationship of substance P to catecholamines, stress, and hypertension.