Document Detail

Safety aspects of GH replacement.
MedLine Citation:
PMID:  19684054     Owner:  NLM     Status:  MEDLINE    
In adults, GH replacement therapy will often be maintained for decades. Owing to the long duration of GH replacement in many adults, it is essential to establish the long-term safety aspects of the treatment. In this review, studies that have investigated the safety profile of long-term GH replacement will be reviewed with an emphasis on studies based on data from the Pfizer International Metabolic Database (KIMS). These studies show that long-term GH replacement in adults is safe and that long-term GH replacement may even improve cardiovascular mortality and morbidity in GH-deficient adults.
Johan Svensson; Bengt-Ake Bengtsson
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-14
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  161 Suppl 1     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S65-74     Citation Subset:  IM    
Department of Endocrinology, Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden. <>
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MeSH Terms
Cardiovascular Diseases / epidemiology*,  mortality,  prevention & control
Databases, Factual
Diabetes Mellitus, Type 2 / chemically induced,  epidemiology*,  metabolism
Human Growth Hormone / administration & dosage,  adverse effects*,  deficiency*
Hypothalamic Neoplasms / epidemiology
Insulin / metabolism
International Cooperation
Neoplasm Recurrence, Local / epidemiology
Neoplasms / chemically induced,  epidemiology*
Pituitary Neoplasms / epidemiology
Risk Assessment
Risk Factors
Reg. No./Substance:
11061-68-0/Insulin; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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