| Safety of antitachycardia pacing in patients with implantable cardioverter defibrillators and severely depressed left ventricular function. | |
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MedLine Citation:
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PMID: 7724387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to investigate the efficacy and safety of antitachycardia pacing (ATP) in third-generation implantable cardioverter defibrillators (ICDs) for terminating spontaneously occurring ventricular tachycardias (VTs) in patients with severely depressed left ventricular (LV) function. Ninety-one patients with active ATP were followed for 16 +/- 13 months. During this period, 775 VT episodes occurring in 36 patients were treated by ATP. The patients were divided into two groups according to their LV ejection fraction (LVEF): group A with LVEF < or = 30% (n = 20), and group B with LVEF > 30% (n = 16). There were no differences between both groups in age, gender, underlying heart disease, indication for ICD therapy, or drug therapy. The VT rates were comparable (group A: 183 +/- 16 beats/min; group B: 180 +/- 21 beats/min; P = NS). Eighty-three percent of all episodes (n = 332) in group A and 93% of the VTs (n = 443) in group B were ATP terminated (P < 0.01). Ten percent of VTs in group A were accelerated by ATP into the ventricular fibrillation zone versus 2% in group B (P < 0.01). The individual termination rate and acceleration rate per patient were comparable in both groups. All VT episodes unresponsive to ATP were converted by backup shocks. The efficacy of first-shock therapy was similar in both groups (group A: 89%; group B: 97%; P = NS). The proportion of patients who needed at least one backup shock for unsuccessful ATP was comparable in both groups (group A: 65%; group B: 56%; P = NS).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Heisel; J Neuzner; E Himmrich; H F Pitschner; A Liebrich; J Jung; S Sen |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 18 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-05-19 Completed Date: 1995-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Universitätskliniken des Saarlandes, Homburg/Saar, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Defibrillators, Implantable* Equipment Design Female Follow-Up Studies Humans Male Middle Aged Pacemaker, Artificial* Retrospective Studies Stroke Volume / physiology Tachycardia, Ventricular / epidemiology, physiopathology, therapy* Time Factors Ventricular Dysfunction, Left / physiopathology* Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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