| Safety of Universal Provision of Iron through Home Fortification of Complementary Foods in Malaria-Endemic Areas. | |
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MedLine Citation:
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PMID: 22797992 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Home fortification of complementary foods with iron and other micronutrients is a low-cost strategy for filling nutrient gaps in the diets of infants and young children, but there has been uncertainty about the safety of universal provision of iron via home fortification in malaria-endemic areas. Based on the current understanding of the potential mechanisms of adverse effects of iron, the risk can probably be minimized by using the lowest possible efficacious dose of iron, preferably delivered in small amounts throughout the day with food, to minimize spikes in plasma nontransferrin-bound iron and large amounts of unabsorbed iron in the gastrointestinal tract. Results from 6 home fortification studies in malaria-endemic areas showed no increased risk of morbidity (including malaria), but these studies were not powered to rule out a modest increase in the risk of severe adverse events. At present, the safest option is to implement home fortification in the context of comprehensive malaria control strategies, as recommended in recent WHO guidelines. |
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Authors:
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Kathryn G Dewey; Lacey M Baldiviez |
Publication Detail:
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Type: Journal Article Date: 2012-07-01 |
Journal Detail:
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Title: Advances in nutrition (Bethesda, Md.) Volume: 3 ISSN: 2156-5376 ISO Abbreviation: Adv Nutr Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101540874 Medline TA: Adv Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 555-9 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Program in International and Community Nutrition, University of California, Davis, Davis, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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