| Safety and Tolerability of Antiretrovirals during Pregnancy. | |
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MedLine Citation:
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PMID: 21603231 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Combination antiretroviral therapy (CART) dramatically decreases mother-to-child HIV-1 transmission (MTCT), but maternal adverse events are not infrequent. A review of 117 locally followed pregnancies revealed 7 grade ≥3 AEs possibly related to antiretrovirals, including 2 hematologic, 3 hepatic, and 2 obstetric cholestasis cases. A fetal demise was attributed to obstetric cholestasis, but no maternal deaths occurred. The drugs possibly associated with these AE were zidovudine, nelfinavir, lopinavir/ritonavir, and indinavir. AE or intolerability required discontinuation/substitution of nevirapine in 16% of the users, zidovudine in 10%, nelfinavir in 9%, lopinavir/ritonavir in 1%, but epivir and stavudine in none. In conclusion, nevirapine, zidovudine, and nelfinavir had the highest frequency of AE and/or the lowest tolerability during pregnancy. Although nevirapine and nelfinavir are infrequently used in pregnancy at present, zidovudine is included in most MTCT preventative regimens. Our data emphasize the need to revise the treatment recommendations for pregnant women to include safer and better-tolerated drugs. |
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Authors:
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Adriana Weinberg; Jeri Forster-Harwood; Jill Davies; Elizabeth J McFarland; Jennifer Pappas; Kay Kinzie; Emily Barr; Suzanne Paul; Carol Salbenblatt; Elizabeth Soda; Anna Vazquez; Myron J Levin |
Publication Detail:
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Type: Journal Article Date: 2011-04-11 |
Journal Detail:
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Title: Infectious diseases in obstetrics and gynecology Volume: 2011 ISSN: 1098-0997 ISO Abbreviation: Infect Dis Obstet Gynecol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9318481 Medline TA: Infect Dis Obstet Gynecol Country: Egypt |
Other Details:
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Languages: eng Pagination: 867674 Citation Subset: IM |
Affiliation:
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School of Medicine University of Colorado Denver, Research Complex 2, Mail Stop 8604, 12700 E. 19th Avenue, Aurora, CO 80045, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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