| Safety of Thiopurines and Anti-TNF-α Drugs During Pregnancy in Patients With Inflammatory Bowel Disease. | |
| | |
MedLine Citation:
|
PMID: 23318480 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES:The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these drugs in this situation is limited. Our aim is to assess the safety of thiopurines and anti-TNF-α drugs for the treatment of inflammatory bowel disease (IBD) during pregnancy.METHODS:Retrospective, multicenter study in IBD patients. Pregnancies were classified according to the therapeutic regimens during pregnancy or during the 3 months before the conception: non-exposed group, pregnancies exposed to thiopurines alone (group A), and pregnancies exposed to anti-TNF-α drugs (group B). An unfavorable Global Pregnancy Outcome (GPO) was considered if pregnancy developed with obstetric complications in the mother and in the newborn.RESULTS:A total of 187 pregnancies in the group A, 66 pregnancies in the group B, and 318 pregnancies in the non-exposed group were included. The rate of unfavorable GPO was different among the three groups (31.8% in non-exposed group, 21.9% in group A, and 34.8% in group B), being lower in pregnancies under thiopurines than among non-exposed (P=0.01). The rate of pregnancy complications was similar among the three groups (27.7% in non-exposed, 20.9% in group A, and 30.3% in group B). The rate of neonatal complications was different among the three groups (23.3% in non-exposed group, 13.9% in group A, and 21.2% in group B), being lower in pregnancies under thiopurines than among non-exposed (P=0.01). In the multivariate analysis, the treatment with thiopurines (odds ratio=0.6; 95% confidence interval=0.4-0.9, P=0.02) was the only predictor of favorable GPO, whereas maternal age >35 years at conception was the only predictor of unfavorable GPO. The treatment with anti-TNF-α drugs was not associated with an unfavorable GPO.CONCLUSION:The treatment with thiopurines and anti-TNF-α drugs does not seem to increase the risk of complications during pregnancy and does seem to be safe for the newborn.Am J Gastroenterol advance online publication, 15 January 2013; doi:10.1038/ajg.2012.430. |
| | |
Authors:
|
M J Casanova; M Chaparro; E Domènech; M Barreiro-de Acosta; F Bermejo; E Iglesias; F Gomollón; L Rodrigo; X Calvet; M Esteve; E García-Planella; S García-López; C Taxonera; M Calvo; M López; D Ginard; M Gómez-García; E Garrido; J L Pérez-Calle; B Beltrán; M Piqueras; C Saro; B Botella; C Dueñas; A Ponferrada; M Mañosa; V García-Sánchez; J Maté; J P Gisbert |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: - ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Gastroenterology, Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: American Journal of Gastroenterology Lecture: Intestinal Microbiota and the Role of Fecal Microbiota...
Next Document: Gastric Acid Secretion: Still Relevant?