| Safety of theta burst transcranial magnetic stimulation: a systematic review of the literature. | |
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MedLine Citation:
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PMID: 21221011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theta burst stimulation (TBS) protocols have recently emerged as a method to transiently alter cortical excitability in the human brain through repetitive transcranial magnetic stimulation. TBS involves applying short trains of stimuli at high frequency repeated at intervals of 200 milliseconds. Because repetitive transcranial magnetic stimulation is known to carry a risk of seizures, safety guidelines have been established. TBS has the theoretical potential of conferring an even higher risk of seizure than other repetitive transcranial magnetic stimulation protocols because it delivers high-frequency bursts. In light of the recent report of a seizure induced by TBS, the safety of this new protocol deserves consideration. We performed an English language literature search and reviewed all studies published from May 2004 to December 2009 in which TBS was applied. The adverse events were documented, and crude risk was calculated. The majority of adverse events attributed to TBS were mild and occurred in 5% of subjects. Based on this review, TBS seems to be a safe and efficacious technique. However, given its novelty, it should be applied with caution. Additionally, this review highlights the need for rigorous documentation of adverse events associated with TBS and intensity dosing studies to assess the seizure risk associated with various stimulation parameters (e.g., frequency, intensity, and location). |
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Authors:
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Lindsay Oberman; Dylan Edwards; Mark Eldaief; Alvaro Pascual-Leone |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Volume: 28 ISSN: 1537-1603 ISO Abbreviation: J Clin Neurophysiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-08-05 Completed Date: 2011-12-07 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8506708 Medline TA: J Clin Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 67-74 Citation Subset: IM |
Affiliation:
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Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Cortex
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physiology* Humans PubMed / statistics & numerical data Theta Rhythm / physiology* Time Factors Transcranial Magnetic Stimulation / methods* |
| Grant Support | |
ID/Acronym/Agency:
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F32MH080493/MH/NIMH NIH HHS; K24 RR018875/RR/NCRR NIH HHS; K24 RR018875-05/RR/NCRR NIH HHS; UL1 RR025758/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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