Document Detail

Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting.
MedLine Citation:
PMID:  20552618     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been shown to increase bleeding risks. This study examined the association of perioperative coronary artery bypass grafting (CABG) bleeding risks and SSRI use prior to CABG. HYPOTHESIS: SSRI may be associated with increased bleeding risks after CABG resulting in elevated reoperation rates due to bleeding complications. METHODS: Patients who underwent CABG between 1999 and 2003 (n = 4794) were identified in a tertiary medical center. SSRI use (n = 246) was determined using inpatient pharmacy records. Outcomes included primary end point of reoperation due to bleeding complications and other secondary measures. Multivariate regression models were constructed to adjust for baseline differences between SSRI and control groups. RESULTS: Reoperation due to bleeding complications among SSRI users was not significantly different (odds ratio [OR]: 1.14 (0.52-2.47); P = 0.75) compared to the control group. Other secondary outcomes and 30-day mortality (2.0% in SSRI vs 2.1% in control group; P = 0.92) between the 2 groups were similar. However, the adjusted total volume of postoperative red blood cell (RBC) units transfused was higher in the SSRI group. CONCLUSION: We conclude that there is no compelling evidence to limit the use of SSRIs among patients with coronary artery disease who undergo CABG given the current evidence. Further research may be needed on individual SSRI medications.
Glen L Xiong; Wei Jiang; Robert M Clare; Linda K Shaw; Peter K Smith; Christopher M O'Connor; K Ranga; R Krishnan; L Kristin Newby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  33     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E94-8     Citation Subset:  IM    
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Academic Medical Centers
Blood Coagulation / drug effects
Blood Loss, Surgical
Chi-Square Distribution
Coronary Artery Bypass* / adverse effects,  mortality
Erythrocyte Transfusion
Logistic Models
Middle Aged
North Carolina
Odds Ratio
Postoperative Hemorrhage / chemically induced,  surgery
Propensity Score
Risk Assessment
Risk Factors
Serotonin Uptake Inhibitors / adverse effects,  therapeutic use*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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