| Safety of selective serotonin reuptake inhibitor use prior to coronary artery bypass grafting. | |
| | |
MedLine Citation:
|
PMID: 20552618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been shown to increase bleeding risks. This study examined the association of perioperative coronary artery bypass grafting (CABG) bleeding risks and SSRI use prior to CABG. HYPOTHESIS: SSRI may be associated with increased bleeding risks after CABG resulting in elevated reoperation rates due to bleeding complications. METHODS: Patients who underwent CABG between 1999 and 2003 (n = 4794) were identified in a tertiary medical center. SSRI use (n = 246) was determined using inpatient pharmacy records. Outcomes included primary end point of reoperation due to bleeding complications and other secondary measures. Multivariate regression models were constructed to adjust for baseline differences between SSRI and control groups. RESULTS: Reoperation due to bleeding complications among SSRI users was not significantly different (odds ratio [OR]: 1.14 (0.52-2.47); P = 0.75) compared to the control group. Other secondary outcomes and 30-day mortality (2.0% in SSRI vs 2.1% in control group; P = 0.92) between the 2 groups were similar. However, the adjusted total volume of postoperative red blood cell (RBC) units transfused was higher in the SSRI group. CONCLUSION: We conclude that there is no compelling evidence to limit the use of SSRIs among patients with coronary artery disease who undergo CABG given the current evidence. Further research may be needed on individual SSRI medications. |
| | |
Authors:
|
Glen L Xiong; Wei Jiang; Robert M Clare; Linda K Shaw; Peter K Smith; Christopher M O'Connor; K Ranga; R Krishnan; L Kristin Newby |
Related Documents
:
|
20685168 - Music interventions in patients during coronary angiographic procedures: a randomized c... 17893498 - "provencaresm": a provider-driven pay-for-performance program for acute episodic cardia... 6179228 - Effects of dexamethason on the early postoperative course after coronary artery bypass ... 19007688 - Impact of clopidogrel in patients with acute coronary syndromes requiring coronary arte... 15207418 - Is the kennard effect supported by clinical evidence? 21740118 - Factors associated with delay to pituitary adenoma diagnosis in patients with visual loss. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-21 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: E94-8 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA. gxiong@ucdavis.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Academic Medical Centers Aged Blood Coagulation / drug effects Blood Loss, Surgical Chi-Square Distribution Coronary Artery Bypass* / adverse effects, mortality Erythrocyte Transfusion Female Hematocrit Humans Logistic Models Male Middle Aged North Carolina Odds Ratio Postoperative Hemorrhage / chemically induced, surgery Propensity Score Registries Reoperation Risk Assessment Risk Factors Serotonin Uptake Inhibitors / adverse effects, therapeutic use* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-stimulated peripheral nerve regeneration within asymmetrically porous PLGA/Pluronic F127 ...
Next Document: Ortner's Syndrome: A Multifactorial Cardiovocal Syndrome.