Document Detail


Safety of influenza vaccine administration in egg-allergic patients.
MedLine Citation:
PMID:  20368312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Current guidelines recommend that egg-allergic patients receive an influenza vaccine skin test before the influenza vaccine. This study evaluated the safety of bypassing the skin test and administering graded doses of influenza vaccine to egg-allergic children. METHODS: We conducted a retrospective chart-review study of egg-allergic patients aged 6 months to 18 years who received the vaccine skin test and/or a 2-dose graded influenza vaccine. Between influenza seasons 2002-2003 and 2006-2007, egg-allergic patients underwent a vaccine skin test before influenza vaccine administration. Starting in 2006-2007, the skin test was removed from our protocol and egg-allergic patients received the influenza vaccine in 2 graded doses. All vaccinated patients were observed for adverse reactions. RESULTS: Two hundred sixty-one egg-allergic patients were evaluated for influenza vaccine administration, and 171 went on to receive the vaccine. Of the 56 patients who received the skin test before the influenza vaccine, 95% (exact 95% confidence interval [CI]: 85.1-98.9) tolerated the vaccine without a serious adverse reaction. This rate was unchanged after the vaccine skin test was removed from the protocol. Of the 115 patients who received the vaccine without a preceding skin test, 97% (exact 95% CI: 91.3-99.0) tolerated the vaccine without serious adverse reaction. The tolerance rate ratio was 1.01 (95% CI: 0.97-1.06). CONCLUSION: The results of our study suggest that egg-allergic patients without anaphylaxis to egg may safely receive the influenza vaccine in a 2-dose, graded fashion without a vaccine skin test.
Authors:
Erica Y Chung; Lin Huang; Lynda Schneider
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-05
Journal Detail:
Title:  Pediatrics     Volume:  125     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1024-30     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Children's Hospital Boston, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anaphylaxis / immunology,  prevention & control
Centers for Disease Control and Prevention (U.S.)
Child
Child, Preschool
Desensitization, Immunologic
Dose-Response Relationship, Drug
Egg Hypersensitivity / immunology*,  prevention & control
Female
Humans
Immunization Schedule
Infant
Influenza Vaccines / administration & dosage*,  adverse effects,  contraindications,  immunology*
Intradermal Tests
Male
Retrospective Studies
United States
Chemical
Reg. No./Substance:
0/Influenza Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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