Document Detail

Safety and feasibility of collateral blood flow augmentation after intravenous thrombolysis.
MedLine Citation:
PMID:  21350210     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator.
METHODS: We conducted an open-label pilot study of partial aortic occlusion after thrombolysis. The primary end point was all serious adverse events within 30 days of treatment.
RESULTS: None of the 22 patients enrolled developed symptomatic parenchymal hemorrhages. Asymptomatic hemorrhagic transformation occurred in 9 patients. Procedure-related adverse events were limited to groin complications (n=13). Seventy-seven percent of patients experienced neurological improvement (≥4-point improvement of the National Institutes of Health Stroke Scale score).
CONCLUSIONS: Partial aortic occlusion as an adjunct to thrombolysis in the treatment of acute stroke appears safe. Studies aimed at determining the efficacy of this therapeutic approach are warranted.
Derek J Emery; Peter D Schellinger; Daniel Selchen; Andre G Douen; Richard Chan; Ashfaq Shuaib; Kenneth S Butcher
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2011-02-24
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  42     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  2011-05-31     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1135-7     Citation Subset:  IM    
Department of Radiology, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Aged, 80 and over
Aorta, Abdominal / physiopathology
Balloon Occlusion / adverse effects,  instrumentation,  methods*
Cerebrovascular Circulation / drug effects,  physiology*
Combined Modality Therapy / instrumentation,  methods*
Fibrinolytic Agents / administration & dosage
Hypoxia-Ischemia, Brain / physiopathology,  therapy*
Infusions, Intravenous / methods
Middle Aged
Pilot Projects
Thrombolytic Therapy / methods*
Tissue Plasminogen Activator / administration & dosage
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator

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