| Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus. | |
| | |
MedLine Citation:
|
PMID: 21078609 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: The use of bovine thrombin has been an effective approach to aiding hemostasis during surgery for over 60 years. Its use has a reported association with the development of antibodies to coagulation factors with limited evidence to the clinical significance. METHODS: The Collaborative Delphi survey methodology was used to develop a consensus on specified topic areas from a panel of 12 surgeons/scientists who have had experience with topical thrombins; it consisted of 2 rounds of a Web-based survey and a final live discussion. RESULTS: Some key issues that reached consensus included: bovine, human plasma-derived and recombinant human thrombin are equally effective hemostatic agents with similar adverse event rates, and immunogenicity to a topical protein rarely translate into adverse events. CONCLUSIONS: Although a risk of immunogenicity is associated with all topical thrombins, no conclusive clinical evidence is available that these antibodies have any significant effect on short- and long-term clinical consequences. |
| | |
Authors:
|
Mohit Bhandari; Frederick A Ofosu; Nigel Mackman; Craig Jackson; Cataldo Doria; John E Humphries; Sateesh C Babu; Thomas L Ortel; David Hoffman Van Thiel; Jeanine M Walenga; Rakesh Wahi; Kevin Hong To Teoh; Jawed Fareed |
Related Documents
:
|
7092269 - Treatment of pustulosis palmaris et plantaris with oral doses of colchicine. 6781659 - Relapse rate and long-term management of plaque psoriasis after treatment with photoche... 11148479 - Thioguanine for refractory psoriasis: a 4-year experience. 17472689 - Pimecrolimus 1% cream in the treatment of vulvar lichen sclerosus in postmenopausal women. 11702619 - Comparison of the efficacy and safety of a combination topical gel formulation of benzo... 8680979 - Dramatic response to levamisole and low-dose prednisolone in 23 patients with oral lich... 7857349 - Therapeutic efficacy and safety of pidotimod in the treatment of urinary tract infectio... 20224709 - Treatment of unruptured intracranial aneurysms in south korea in 2006 : a nationwide mu... 15126089 - Improved skin flap survival after local heat preconditioning in pigs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-15 |
Journal Detail:
|
Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 17 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
|
Languages: eng Pagination: 39-45 Citation Subset: IM |
Affiliation:
|
McMaster University, Hamilton, ON, Canada. bhandam@mcmaster.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Global fibrinolytic capacity in neonatal sepsis.
Next Document: Evaluation and treatment of neonatal thrombus formation in 17 patients.