| Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. | |
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MedLine Citation:
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PMID: 23024696 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. Participants were required to record adverse events and to rate cold-related issues in a diary throughout the investigation period. Nasal secretions were sampled at acute colds and screened for viruses. Results. A total of 293 adverse events occurred with Echinacea and 306 with placebo treatment. Nine and 10% of participants experienced adverse events, which were at least possibly related to the study drug (adverse drug reactions). Thus, the safety of Echinacea was noninferior to placebo. Echinacea reduced the total number of cold episodes, cumulated episode days within the group, and pain-killer medicated episodes. Echinacea inhibited virally confirmed colds and especially prevented enveloped virus infections (P < 0.05). Echinacea showed maximal effects on recurrent infections, and preventive effects increased with therapy compliance and adherence to the protocol. Conclusions. Compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio. |
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Authors:
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M Jawad; R Schoop; A Suter; P Klein; R Eccles |
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Publication Detail:
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Type: Journal Article Date: 2012-09-16 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2012 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-01 Completed Date: 2012-10-02 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: United States |
Other Details:
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Languages: eng Pagination: 841315 Citation Subset: - |
Affiliation:
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Common Cold Centre and Healthcare, Cardiff University, Cardiff CF10 3XQ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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