Document Detail

Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production.
MedLine Citation:
PMID:  20816003     Owner:  NLM     Status:  MEDLINE    
Poor production of breast milk is the most frequent cause of breast lactation failure. Often, physician prescribe medications or other substances to solve this problem. The use of galactogogues should be limited to those situations in which reduced milk production from treatable causes has been excluded. One of the most frequent indication for the use of galactogogues is the diminution of milk production in mothers using indirect lactation, particularly in the case of preterm birth. The objective of this review is to analyze to the literature relating to the principal drugs used as galactogogues (metoclopramide, domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues based on herbs and other natural substances (fenugreek, galega and milk thistle). We have evaluated their mechanism of action, transfer to maternal milk, effectiveness and potential side effects for mother and infant, suggested doses for galactogogic effect, and recommendation for breastfeeding.
Antonio Alberto Zuppa; Paola Sindico; Claudia Orchi; Chiara Carducci; Valentina Cardiello; Costantino Romagnoli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques     Volume:  13     ISSN:  1482-1826     ISO Abbreviation:  J Pharm Pharm Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807281     Medline TA:  J Pharm Pharm Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  162-74     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy.
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MeSH Terms
Breast Feeding*
Galactogogues / adverse effects,  pharmacology*
Infant, Newborn
Infant, Premature
Lactation / drug effects*
Plant Extracts / adverse effects,  pharmacology
Premature Birth
Reg. No./Substance:
0/Galactogogues; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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