Document Detail

Safety and efficacy of a bolus injection of landiolol hydrochloride as a premedication for multidetector-row computed tomography coronary angiography.
MedLine Citation:
PMID:  23037522     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We evaluated the safety and efficacy of a bolus injection of landiolol hydrochloride, an ultrashort-acting β1-selective antagonist, as an additional treatment after premedication with an oral β-blocker to reduce heart rate prior to multidetector-row computed tomography (MDCT) coronary angiography (CAG).
METHODS AND RESULTS: A total of 458 patients who underwent MDCT CAG were retrospectively enrolled. Image quality and hemodynamic parameters were compared in patients before and after approval of landiolol hydrochloride. If heart rate reduction was insufficient after premedication with an oral β-blocker, a bolus injection of landiolol hydrochloride (n=66) or other drugs (n=30) was used. The percentage of evaluable images per segment in patients after approval of landiolol (99.3%) was greater than that in patients before approval of landiolol (97.4%, P<0.01). Heart rates before scanning in patients receiving landiolol hydrochloride were similar to those receiving other drugs. Heart rate was significantly reduced approximately 5 min after injection of landiolol hydrochloride and increased shortly. No decrease in systolic blood pressure or other adverse effects was observed.
CONCLUSIONS: Bolus injection of landiolol hydrochloride sufficiently reduced heart rate without significantly reducing systolic blood pressure and produced a high percentage of evaluable images, suggesting that bolus injection of landiolol hydrochloride as an additional pretreatment is feasible in MDCT CAG.
Kazuhiro Osawa; Toru Miyoshi; Shuhei Sato; Noriaki Akagi; Yusuke Morimitsu; Kazufumi Nakamura; Kunihisa Kohno; Kengo Kusano; Susumu Kanazawa; Hiroshi Ito
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-10-03
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects,  pharmacology*
Aged, 80 and over
Coronary Angiography / methods*
Heart Rate / drug effects*
Middle Aged
Morpholines / adverse effects,  pharmacology*
Multidetector Computed Tomography / methods*
Retrospective Studies
Time Factors
Urea / adverse effects,  analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Morpholines; 133242-30-5/landiolol; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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