Document Detail

Safety of CETP inhibition.
MedLine Citation:
PMID:  23010697     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Cholesteryl ester transfer protein (CETP)-inhibiting drugs effectively raise HDL cholesterol. In 2007, the CETP inhibitor torcetrapib unexpectedly showed increased fatality and cardiovascular events, possibly related to increased blood pressure and aldosterone levels caused by torcetrapib. Since then, novel CETP inhibiting drugs have been investigated. This review will discuss the safety of the CETP-inhibiting drugs.
RECENT FINDINGS: The novel CETP inhibitors dalcetrapib, evacetrapib and anacetrapib did not show harmful effects on blood pressure or aldosterone levels. Ultrasound brachial artery flow-mediated vasodilation, carotid MRI and (18)F-fluordeoxyglucose PET imaging studies, showed that dalcetrapib therapy had neither harmful nor beneficial effects on endothelial function, atherosclerosis progression, or vessel wall inflammation. Recently, the clinical endpoint study investigating dalcetrapib was announced to be terminated early, after the second interim analysis showed that dalcetrapib lacked clinically meaningful efficacy.
SUMMARY: Dalcetrapib, evacetrapib and anacetrapib did not show the harmful effects on aldosterone and blood pressure that were exhibited by torcetrapib, indicating that CETP inhibition is well tolerated. So far CETP inhibition did not show beneficial effects on clinical outcome. The phase III study with anacetrapib will give final answers on whether CETP inhibition can reduce cardiovascular events.
Raphaël Duivenvoorden; Zahi A Fayad
Related Documents :
12188717 - Volume-term theories, sogami-ise potential, and the langmuir model for phase separation...
15841207 - Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and bloo...
24475427 - Lipoprotein (a): more than a bystander in the etiology of hypertension? a study on esse...
11035457 - Hypertension awareness, detection and treatment in a university community: results of a...
8944507 - The continent sigmoid urinary reservoir--an experimental study in pigs.
19168897 - Intraocular pressure and calculated diastolic ocular perfusion pressure during three si...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  23     ISSN:  1473-6535     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-04-17     Revised Date:  2013-05-21    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  England    
Other Details:
Languages:  eng     Pagination:  518-24     Citation Subset:  IM    
Academic Medical Center, Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Benzodiazepines / adverse effects,  pharmacology
Cholesterol Ester Transfer Proteins / antagonists & inhibitors*
Oxazolidinones / adverse effects,  pharmacology
Quinolines / adverse effects,  pharmacology
Sulfhydryl Compounds / adverse effects,  pharmacology
Reg. No./Substance:
0/Cholesterol Ester Transfer Proteins; 0/Oxazolidinones; 0/Quinolines; 0/Sulfhydryl Compounds; 12794-10-4/Benzodiazepines; 262352-17-0/torcetrapib; 3D050LIQ3H/dalcetrapib; 51XWV9K850/evacetrapib; P7T269PR6S/anacetrapib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cost-effectiveness of internet and telephone treatment for smoking cessation: an economic evaluation...
Next Document:  Omega-3 fatty acids and coronary heart disease. The final verdict?