Document Detail

Safety of Antibiotic Drugs in Food Animals: Comparison of Findings from Preapproval Studies and Postapproval Experience in the United States with Safety Information in Published Literature.
MedLine Citation:
PMID:  21575776     Owner:  NLM     Status:  In-Data-Review    
Antibiotics are among the most widely prescribed drugs and are generally considered safe for the target species. However, their use has been associated with various adverse toxic effects in target animals, such as allergic reactions, gastrointestinal signs, cardiovascular effects, hypoglycemia, hepatic/renal toxicity, thrombocytopenia, and anaphylaxis. This article provides a qualitative summary of the adverse events observed in target animals during the evaluation of antibiotics by the Food and Drug Administration during both preapproval and postapproval periods. As there is a marked scarcity of published data on safety of antibiotics in food animals, more research is needed in this area.
Tomislav Modric; Sanja Modric; Michael J Murphy; Susan J Bright; Stacey Shults
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Veterinary clinics of North America. Food animal practice     Volume:  27     ISSN:  1558-4240     ISO Abbreviation:  Vet. Clin. North Am. Food Anim. Pract.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511905     Medline TA:  Vet Clin North Am Food Anim Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-405     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Office of Surveillance and Compliance, FDA Center for Veterinary Medicine (CVM), 7519 Standish Place, Rockville, MD 20855, USA.
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