| Safeguarding entry into mitosis: the antephase checkpoint. | |
MedLine Citation:
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PMID: 19841063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maintenance of genomic stability is needed for cells to survive many rounds of division throughout their lifetime. Key to the proper inheritance of intact genome is the tight temporal and spatial coordination of cell cycle events. Moreover, checkpoints are present that function to monitor the proper execution of cell cycle processes. For instance, the DNA damage and spindle assembly checkpoints ensure genomic integrity by delaying cell cycle progression in the presence of DNA or spindle damage, respectively. A checkpoint that has recently been gaining attention is the antephase checkpoint that acts to prevent cells from entering mitosis in response to a range of stress agents. We review here what is known about the pathway that monitors the status of the cells at the brink of entry into mitosis when cells are exposed to insults that threaten the proper inheritance of chromosomes. We highlight issues which are unresolved in terms of our understanding of the antephase checkpoint and provide some perspectives on what lies ahead in the understanding of how the checkpoint functions. |
Authors:
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Cheen Fei Chin; Foong May Yeong |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular and cellular biology Volume: 30 ISSN: 1098-5549 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-14 Revised Date: 2010-07-02 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 22-32 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore S117597, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle Proteins / genetics, physiology Chromosome Segregation / physiology Chromosomes / genetics, physiology* DNA Damage Down-Regulation Humans Interphase / physiology* Mitosis / physiology* Mutation Neoplasm Proteins / genetics, physiology Neoplasms / metabolism, pathology Signal Transduction p38 Mitogen-Activated Protein Kinases / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/CHFR protein, human; 0/Cell Cycle Proteins; 0/Neoplasm Proteins; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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