Document Detail

'Safe oxygen' in acute asthma: prospective trial using 35% Ventimask prior to admission.
MedLine Citation:
PMID:  2512593     Owner:  NLM     Status:  MEDLINE    
There is still some uncertainty as to the best inspired oxygen concentration to use in the treatment of acute asthma before measurement of arterial blood gases can be made. In the absence of published data, we report a prospective study in which 35% oxygen was the initial therapy given to patients with moderate to severe asthma, and arterial blood gases were taken to assess the adequacy of oxygenation and the safety of this method. Forty-five episodes were analyzed and a wide range of PaO2 was observed (8.8-21.3 kPa 66-160 mmHg). No relationship was shown between PaCO2 and either PaO2 or duration of oxygen treatment. It was concluded that 35% oxygen given in acute asthma is both safe and probably adequate. A lesser concentration of oxygen could expose asthmatics to an unacceptable risk of significant hypoxaemia.
D J Ford; R P Rothwell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  83     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1989 May 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand.
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MeSH Terms
Acute Disease
Administration, Inhalation
Asthma / blood,  drug therapy*,  physiopathology
Carbon Dioxide / blood
Emergency Medical Services*
Nebulizers and Vaporizers*
Oxygen / blood,  therapeutic use*
Partial Pressure
Peak Expiratory Flow Rate
Prospective Studies
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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