| Safe ex vivo coronary angiography with isosmotic contrast agent. | |
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MedLine Citation:
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PMID: 8751495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plain-film coronary angiography of the cardiac explant on the operating table should be considered when conventional cardiac catheterization is desired but unavailable. We compared the effects of three contrast solutions on cold-preserved, isolated guinea pig hearts. Hearts were excised, perfused for 30 minutes, and arrested with Plegisol solution at 7 degree C. Twenty minutes after arrest, experimental hearts were perfused with one of three solutions: hyperosmolar Hexabrix solution (n = 6), hyperosmolar Renografin-76 solution (n = 6), or diluted, isosmotic Omnipaque solution (n = 8). The hearts were flushed with cold Plegisol solution 5 minutes later. Control hearts received no contrast during arrest (n = 9). The hearts were reperfused after 1 hour of arrest, and coronary blood flow (in millimeters per minute), left ventricular developed pressure (in millimeters of mercury), and rate of developed pressure (in millimeters of mercury per second) were measured. Endothelium-dependent smooth muscle relaxation to bradykinin administration and endothelium-independent relaxation to sodium nitroprusside administration were also assessed. No significant difference in myocardial or endothelial function was noted between control hearts and hearts perfused with Omnipaque solution. Hearts perfused with Renografin solution or Hexabrix solution, however, were found to have significantly impaired endothelial and myocardial function. We conclude that an isosmotic contrast solution should be used for ex vivo coronary angiography in cold-preserved hearts to avoid impairment of endothelial and myocardial function. |
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Authors:
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D B Schmit; J A Kern; M C Mauney; I L Kron; C G Tribble |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 112 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-24 Completed Date: 1996-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 306-9 Citation Subset: AIM; IM |
Affiliation:
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University of Virginia Health Sciences Center, Charlottesville, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicarbonates / administration & dosage Blood Pressure / drug effects Bradykinin / pharmacology Calcium Chloride / administration & dosage Cardioplegic Solutions / administration & dosage Contrast Media* / pharmacology Coronary Angiography* / methods Coronary Circulation / drug effects Cryopreservation Diatrizoate / pharmacology Diatrizoate Meglumine / pharmacology Drug Combinations Endothelium, Vascular / drug effects Guinea Pigs Heart Arrest, Induced Iohexol / pharmacology Ioxaglic Acid / pharmacology Magnesium / administration & dosage Muscle, Smooth, Vascular / drug effects Myocardial Reperfusion Nitroprusside / pharmacology Osmolar Concentration Potassium Chloride / administration & dosage Safety Sodium Chloride / administration & dosage Vasodilation Vasodilator Agents / pharmacology Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Cardioplegic Solutions; 0/Contrast Media; 0/Drug Combinations; 0/St. Thomas' Hospital cardioplegic solution; 0/Vasodilator Agents; 10043-52-4/Calcium Chloride; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 15078-28-1/Nitroprusside; 58-82-2/Bradykinin; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; 8064-12-8/urovision |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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