| Safe and effective intravenous thrombolysis for acute ischemic stroke caused by left atrial myxoma. | |
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MedLine Citation:
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PMID: 19717026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrial myxoma may be associated with syncope or sudden death attributed to left-sided cardiac outflow obstruction or embolization caused by tumor dislodgement or thrombus formation. Definitive treatment for primary and secondary stroke prevention is surgical resection. The role of thrombolysis in acute brain ischemia in patients with atrial myxoma is not defined. There are few data available regarding safety and efficacy of thrombolytic therapy in acute ischemic strokes caused by atrial myxoma. Prior case reports described partial success using intra-arterial local thrombolysis; however, this is invasive and can be associated with significant complications. A previously reported case of systemic thrombolysis resulted in development of cerebral hemorrhage. We describe a young man who presented with syncope and a dense stroke developing as a complication of atrial myxoma, followed by a remarkable recovery after treatment with intravenous recombinant tissue plasminogen activator and urgent cardiac surgery. Contrary to some expert opinion, systemic thrombolytic therapy may be safely and effectively used to treat acute ischemic strokes from atrial myxoma. |
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Authors:
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Christian D Nagy; Michael Levy; Thomas J Mulhearn; Maryam Shapland; Henry Sun; David D Yuh; Dickson Cheung; Nisha Chandra-Strobos |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Volume: 18 ISSN: 1532-8511 ISO Abbreviation: J Stroke Cerebrovasc Dis Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111633 Medline TA: J Stroke Cerebrovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 398-402 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease
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therapy Adult Brain / blood supply, pathology, physiopathology Brain Ischemia / drug therapy*, etiology, pathology Cardiac Surgical Procedures Cerebral Arteries / drug effects, pathology, physiopathology Echocardiography, Transesophageal Heart Atria / pathology, surgery, ultrasonography Heart Neoplasms / complications*, pathology, surgery Humans Injections, Intravenous Magnetic Resonance Angiography Magnetic Resonance Imaging Male Myxoma / complications*, pathology, surgery Stroke / drug therapy*, etiology, pathology Thrombolytic Therapy / methods* Tissue Plasminogen Activator / administration & dosage Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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