| Sadness in the SUN: Using Computerized Screening to Analyze Correlates of Depression and Adherence in HIV-Infected Adults in the United States. | |
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MedLine Citation:
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PMID: 23199190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract We used a standardized screening tool to examine frequency of depression and its relation to antiretroviral medication adherence among HIV-infected persons on highly active antiretroviral therapy (HAART) in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN Study). This is a prospective observational cohort of 700 HIV-infected patients enrolled between March 2004 and June 2006 in four U.S. cities, who completed a confidential audio computer-assisted self-interview [ACASI] with behavioral risk and health-related questions at baseline and 6-month follow-up visits, including the nine-question PRIME-MD depression screener and a validated 3-day antiretroviral adherence question. Among 539 eligible participants receiving HAART, 14% had depression at baseline (22% women, 12% men). In multivariable analysis using generalized estimating equations (GEE) to account for repeated measurements through 24 months of follow-up, persons who reported depression on a given ACASI were twice as likely to report nonadherence to antiretrovirals on the same ACASI (Odds ratio [OR] 2.02, 95% CI: 1.15, 3.57] for mild/moderate depression versus none); such persons were also less likely to have HIV viral load<400 copies/mL. Self-administered computerized standardized screening tools can identify at-risk individuals with depression who may benefit from interventions to improve antiretroviral adherence. |
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Authors:
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Ellen M Tedaldi; Mary van den Berg-Wolf; James Richardson; Pragna Patel; Marcus Durham; John Hammer; Keith Henry; Sara Metzler; Nur Onen; Lois Conley; Kathy Wood; John T Brooks; Kate Buchacz And The Sun Study Investigators |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AIDS patient care and STDs Volume: 26 ISSN: 1557-7449 ISO Abbreviation: AIDS Patient Care STDS Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607225 Medline TA: AIDS Patient Care STDS Country: United States |
Other Details:
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Languages: eng Pagination: 718-29 Citation Subset: IM; X |
Affiliation:
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1 Temple University School of Medicine , Philadelphia, Pennsylvania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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