Document Detail

Sadness and broken hearts: neurohumoral mechanisms and co-morbidity of ischemic heart disease and psychological depression.
MedLine Citation:
PMID:  17244936     Owner:  NLM     Status:  MEDLINE    
Heart disease and depression are highly co-morbid. Clinical and experimental research over the past 70 years has led to several neurohumoral hypotheses of causative factors present under the conditions of either heart failure or of psychological depression. Some of these hypothesized factors are common to both disorders and are therefore attractive candidates to account for the high incidence of co-occurrence of depression and heart disease. One experimental approach to study the co-morbidity of heart failure and depression has been to study the behavioral, biochemical and physiological changes in a chronic mild stress model of depression and in heart failure induced by experimental myocardial infarction. Our studies have led us to focus on the pro-inflammatory cytokines, in particular tumor necrosis factor (TNF)-alpha, and the renin-angiotensin-aldosterone system. Both of these families of humoral factors are elevated in human heart failure and in depression and the two experimental models we have studied. The demonstrated validity of each of these models will be of great value in elucidating the nature of the actions and interactions of these humoral agents as they contribute to the co-morbid conditions of heart failure and depression.
A K Johnson; A J Grippo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  57 Suppl 11     ISSN:  1899-1505     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-01-24     Completed Date:  2008-03-27     Revised Date:  2008-05-19    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  5-29     Citation Subset:  IM    
Department of Psychology, Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USA.
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MeSH Terms
Behavior, Animal
Chronic Disease
Corticotropin-Releasing Hormone / physiology
Cytokines / physiology*
Depression / complications*,  physiopathology
Depressive Disorder, Major / complications,  physiopathology
Disease Models, Animal
Heart Failure / complications,  physiopathology
Hypothalamo-Hypophyseal System / physiopathology*
Myocardial Ischemia / complications,  physiopathology*
Renin-Angiotensin System / physiology*
Risk Factors
Stress, Psychological / complications*,  physiopathology
Tumor Necrosis Factor-alpha / physiology
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Tumor Necrosis Factor-alpha; 9015-71-8/Corticotropin-Releasing Hormone

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