| Sacral epithelioid angiosarcoma associated with a bleeding diathesis and spinal epidural hematoma: case report. | |
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MedLine Citation:
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PMID: 16572625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epithelioid angiosarcoma of bone is a rare, high-grade lesion that is highly vascular and can be associated with a bleeding diathesis. An association has been reported in angiosarcomas in other locations with coagulopathy from tumor-related disseminated intravascular coagulopathy and fibrinolysis. The authors report the case of a rare occurrence of a primary sacral epithelioid angiosarcoma associated with a large epidural hematoma and a severe bleeding diathesis. A 25-year-old woman presented with weakness, fatigue, neck and low-back pain, and progressive left S-1 radiculopathy. Imaging studies revealed a large ventral epidural hematoma extending from the sacral region rostrally to C-2 and a vascular tumor located in the sacrum. The patient underwent a sacral laminectomy, complicated by postoperative bleeding from the wound, and required massive transfusions. Ultimately, multimodal therapy was required to obtain hemostasis, including the use of endovascular embolization, radiation therapy, and an infusion of epsilon-aminocaproic acid with heparin. This case represents the first report of a primary epithelioid angiosarcoma in the sacrum and emphasizes that the coagulopathy seen in angiosarcoma is also a feature of this epithelioid variant. |
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Authors:
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Rene O Sanchez-Mejia; Steven G Ojemann; Jeff Simko; Uzair B Chaudhary; Jay Levy; Michael T Lawton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery. Spine Volume: 4 ISSN: 1547-5654 ISO Abbreviation: - Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-31 Completed Date: 2006-04-13 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 101223545 Medline TA: J Neurosurg Spine Country: United States |
Other Details:
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Languages: eng Pagination: 246-50 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, University of California, San Francisco 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Blood Transfusion Bone Neoplasms / complications*, drug therapy, pathology, surgery Combined Modality Therapy Doxorubicin / administration & dosage Embolization, Therapeutic Female Hemangiosarcoma / complications*, drug therapy, pathology, surgery Hematoma, Epidural, Spinal Hemorrhagic Disorders Hemostasis Humans Ifosfamide / administration & dosage Laminectomy Magnetic Resonance Imaging Sacrum / pathology, surgery Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin; 3778-73-2/Ifosfamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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