| Saccular intracranial aneurysm: pathology and mechanisms. | |
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MedLine Citation:
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PMID: 22249619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial arteries that develop when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends. Some sIAs remain stable over time, but in others mural cells die, the matrix degenerates, and eventually the wall ruptures, causing life-threatening hemorrhage. The wall of unruptured sIAs is characterized by myointimal hyperplasia and organizing thrombus, whereas that of ruptured sIAs is characterized by a decellularized, degenerated matrix and a poorly organized luminal thrombus. Cell-mediated and humoral inflammatory reaction is seen in both, but inflammation is clearly associated with degenerated and ruptured walls. Inflammation, however, seems to be a reaction to the ongoing degenerative processes, rather than the cause. Current data suggest that the loss of mural cells and wall degeneration are related to impaired endothelial function and high oxidative stress, caused in part by luminal thrombosis. The aberrant flow conditions caused by sIA geometry are the likely cause of the endothelial dysfunction, which results in accumulation of cytotoxic and pro-inflammatory substances into the sIA wall, as well as thrombus formation. This may start the processes that eventually can lead to the decellularized and degenerated sIA wall that is prone to rupture. |
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Authors:
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Juhana Frösen; Riikka Tulamo; Anders Paetau; Elisa Laaksamo; Miikka Korja; Aki Laakso; Mika Niemelä; Juha Hernesniemi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-01-17 |
Journal Detail:
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Title: Acta neuropathologica Volume: 123 ISSN: 1432-0533 ISO Abbreviation: Acta Neuropathol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-24 Completed Date: 2012-09-24 Revised Date: 2012-11-12 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 773-86 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu 5, 00260 Helsinki, Finland. juhana.frosen@hus.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneurysm, Ruptured
/
etiology,
metabolism,
pathology* Animals Cerebral Arterial Diseases / etiology, metabolism, pathology Humans Inflammation / pathology Intracranial Aneurysm / metabolism, pathology* Oxidative Stress Thrombosis / pathology |
| Comments/Corrections | |
Comment In:
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Radiologe. 2012 Sep;52(9):801-2
[PMID:
22930098
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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