Document Detail

Saccharomyces cerevisiae - a model to uncover molecular mechanisms for yeast biofilm biology.
MedLine Citation:
PMID:  22332975     Owner:  NLM     Status:  Publisher    
Microbial biofilms can be defined as multi-cellular aggregates adhering to a surface and embedded in an extracellular matrix. The non-pathogenic yeast, S. cerevisiae, follows the common traits of microbial biofilms with cell-cell and cells-surface adhesion. S. cerevisiae is shown to produce an extracellular matrix, respond to quorum sensing and multi-cellular aggregates have lowered susceptibility to antifungals. Adhesion is mediated by a family of cell surface proteins of which Flo11 has been shown to be essential for biofilm development. FLO11 expression is regulated via a number of regulatory pathways including the protein kinase A and a MAPK pathway. Advanced genetic tools and resources have been developed for S. cerevisiae including a deletion mutant-strain collection in a biofilm forming strain background and GFP-fusion protein collections. Furthermore, S. cerevisiae biofilm is well applied for confocal laser scanning microscopy and fluorophore tagging of proteins, DNA and RNA. These techniques can be used to uncover the molecular mechanisms for biofilm development, drug resistance and for the study of molecular interactions, cell-response to environmental cues, cell to cell variation and niches in S. cerevisiae biofilm. Being closely related to Candida species, S. cerevisiae is a model to investigate biofilms of pathogenic yeast. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Rasmus K Bojsen; Kaj Scherz Andersen; Birgitte Regenberg; Christine Imbert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-14
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  -     ISSN:  1574-695X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Department of Systems Biology, Technical University of Denmark, DK-2800 Kgs., Lyngby, Denmark.
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