Document Detail


The Saccharomyces cerevisiae BEM1 homolog in Neurospora crassa promotes coordinated cell behavior resulting in cell fusion.
MedLine Citation:
PMID:  22906237     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Directed growth or movement is a common feature of microbial development and propagation. In polar growing filamentous fungi, directed growth requires the interaction of signal sensing machineries with factors controlling polarity and cell tip extension. In N. crassa an unusual mode of cell-cell signaling mediates mutual attraction of germinating spores, which subsequently fuse. During directed growth of the two fusion partners, the cells coordinately alternate between two physiological stages, probably associated with signal sending and receiving. Here, we show that the Saccharomyces cerevisiae BEM1 homolog in N. crassa is essential for the robust and efficient functioning of this MAP kinase based signaling system. BEM1 localizes to growing hyphal tips suggesting a conserved function as a polarity component. In the absence of BEM1, activation of MAK-2, a MAP kinase essential for germling fusion, is strongly reduced and delayed. Germling interactions become highly instable and successful fusion is greatly reduced. In addition, BEM1 is actively recruited around the forming fusion pore, suggesting potential functions after cell-cell contact has been established. By genetically dissecting the contribution of BEM1 to additional various polarization events, we also obtained first hints that BEM1 might function in different protein complexes controlling polarity and growth direction.
Authors:
Timo Schürg; Ulrike Brandt; Christian Adis; André Fleißner
Related Documents :
20726687 - Defining a threshold surface density of vitronectin for the stable expansion of human e...
22451657 - Engulfment protein gulp is regulator of transforming growth factor-β response in ovari...
22562397 - The activation of protease-activated receptor 1 mediates proliferation and invasion of ...
22851857 - Cellular and molecular mechanisms of intestinal fibrosis.
23024807 - Cd80 and cd86 differentially regulate mechanical interactions of t-cells with antigen-p...
12690907 - Ergosterol (major sterol of baker's and brewer's yeast extracts) inhibits the growth of...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Molecular microbiology     Volume:  -     ISSN:  1365-2958     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Institut für Genetik, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Random student drug testing as a school-based drug prevention strategy.
Next Document:  Detection of hssS, hssR, hrtA, and hrtB genes and their expression by hemin in Staphylococcus epider...