Document Detail

The Saccharomyces cerevisiae BEM1 homolog in Neurospora crassa promotes coordinated cell behavior resulting in cell fusion.
MedLine Citation:
PMID:  22906237     Owner:  NLM     Status:  Publisher    
Directed growth or movement is a common feature of microbial development and propagation. In polar growing filamentous fungi, directed growth requires the interaction of signal sensing machineries with factors controlling polarity and cell tip extension. In N. crassa an unusual mode of cell-cell signaling mediates mutual attraction of germinating spores, which subsequently fuse. During directed growth of the two fusion partners, the cells coordinately alternate between two physiological stages, probably associated with signal sending and receiving. Here, we show that the Saccharomyces cerevisiae BEM1 homolog in N. crassa is essential for the robust and efficient functioning of this MAP kinase based signaling system. BEM1 localizes to growing hyphal tips suggesting a conserved function as a polarity component. In the absence of BEM1, activation of MAK-2, a MAP kinase essential for germling fusion, is strongly reduced and delayed. Germling interactions become highly instable and successful fusion is greatly reduced. In addition, BEM1 is actively recruited around the forming fusion pore, suggesting potential functions after cell-cell contact has been established. By genetically dissecting the contribution of BEM1 to additional various polarization events, we also obtained first hints that BEM1 might function in different protein complexes controlling polarity and growth direction.
Timo Schürg; Ulrike Brandt; Christian Adis; André Fleißner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Molecular microbiology     Volume:  -     ISSN:  1365-2958     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Institut für Genetik, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.
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