Document Detail

Saccharomyces boulardii for the treatment of Clostridium difficile-associated colitis.
MedLine Citation:
PMID:  9220059     Owner:  NLM     Status:  MEDLINE    
S. boulardii has been investigated in Europe and the US, and preliminary reports indicate that it is safe and effective in conjunction with vancomycin or metronidazole for the treatment of CDC, predominantly in patients who develop recurrence. S. boulardii in combination with vancomycin or metronidazole has not been shown to be more effective than either of these agents alone for treatment of a first episode of CDC. In addition, S. boulardii has not been studied in immunocompromised patients who may be at risk for developing fungemia. Ultimately, large-scale clinical studies are necessary to determine whether S. boulardii should be routinely used to treat patients with recurrent CDC. S. boulardii is currently undergoing Phase III clinical trials for CDC treatment in the US. Clinicians interested in information regarding participation in current studies may contact Biocodex Inc., in Seattle, Washington.
J T Eddy; M K Stamatakis; E H Makela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  31     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-18     Completed Date:  1997-09-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  919-21     Citation Subset:  IM    
School of Pharmacy, West Virginia University, Morgantown 26506, USA.
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MeSH Terms
Anti-Bacterial Agents / adverse effects,  therapeutic use
Antitrichomonal Agents / therapeutic use
Clinical Trials, Phase III as Topic
Clostridium difficile*
Drug Therapy, Combination
Enterocolitis, Pseudomembranous / epidemiology,  microbiology*,  therapy*
Metronidazole / therapeutic use
Risk Factors
Vancomycin / therapeutic use
Yeast, Dried / therapeutic use*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antitrichomonal Agents; 1404-90-6/Vancomycin; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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