| Saccharomyces boulardii fungemia caused by treatment with a probioticum. | |
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MedLine Citation:
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PMID: 22605806 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Saccharomyces cerevisiae, known as baker's yeast, is normally considered a non-pathogenic yeast. A genetically very similar subtype, S boulardii, is used in a probioticum (Sacchaflor) to prevent antibiotic-associated diarrhoea and in the treatment of recurrent Clostridium difficile associated diarrhoea. The authors present a case report of a 79-year-old woman with rheumatoid arthritis, who after a bowel resection developed S boulardii fungemia. Her postoperative course was complicated by nutritional problems, anaemia and several nosocomial infections including recurrent C difficile associated diarrhoea. The diarrhoea was treated with metronidazole, vancomycin and Sacchaflor. After 13 days of treatment, the patient developed fungemia with S boulardii. Treatment with Sacchaflor was immediately discontinued and the patient was successfully treated with amphotericin B. Fungemia is a rare, but a serious complication to treatment with probiotics. Accordingly, the authors find it important to remind the clinicians of this risk when prescribing probiotics especially to immunocompromised patients. |
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Authors:
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Julie Bjerre Thygesen; Henning Glerup; Britta Tarp |
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Publication Detail:
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Type: Journal Article Date: 2012-03-27 |
Journal Detail:
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Title: BMJ case reports Volume: 2012 ISSN: 1757-790X ISO Abbreviation: BMJ Case Rep Publication Date: 2012 |
Date Detail:
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Created Date: 2012-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526291 Medline TA: BMJ Case Rep Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Regionshospitalet Silkeborg, Silkeborg, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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