Document Detail

Saccadic intrusions: review and update.
MedLine Citation:
PMID:  23302805     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: This work reviews saccadic intrusions focusing on recent developments in pathophysiology and treatment.
RECENT FINDINGS: Saccadic intrusions have been recognized as features of oculomotor apraxia type 2 and neuromyelitis optica. Novel fixation instabilities have been identified such as 'staircase' square wave jerks, or the pervasive ocular microtremor seen in Parkinson's disease. Although evidence supports a network underlying the pathophysiology of square wave jerks involving cerebral hemispheres, subcortex, brainstem and cerebellum, the debate regarding the pathogenesis of ocular flutter and opsoclonus centres on a cerebellar and brainstem hypotheses. The cerebellar hypothesis explains functional imaging findings, whereas the brainstem hypothesis provides possible explanations for some therapeutic responses as well as accompanying myoclonus, startle and tremor. A study of immunotherapies in children with opsoclonus-myoclonus syndrome found that treatment combinations were more effective than corticotropin alone.
SUMMARY: Recognition of saccadic intrusions can assist in the diagnosis of neurological disease. We are gaining new insights about pathogenesis through models, functional imaging and genetic approaches.
João Lemos; Eric Eggenberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in neurology     Volume:  26     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Department of Neurology, Coimbra University Hospital, Coimbra, Portugal.
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