Document Detail


Saccades in Huntington's disease: predictive tracking and interaction between release of fixation and initiation of saccades.
MedLine Citation:
PMID:  1828547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared saccadic eye movements in 21 patients with Huntington's disease (HD) and 21 normal subjects. In a predictive tracking task, HD patients were unable to anticipate normally the timing and location of a visual target that alternated its position predictably (+/- 10 degrees, 0.5 Hz; mean latency of +170 msec in HD and -78 msec in normal subjects). HD patients and normal subjects, however, showed comparable decreases in saccade latency (110 msec in HD, 124 msec in normal subjects) when the fixation target was turned off 200 msec before (gap task) versus 200 msec after (overlap task) the appearance of an unexpected peripheral stimulus. Taken together, these findings support the idea that HD patients show greater defects in initiating internally generated than in initiating externally triggered saccades. This dichotomy is likely due to involvement of frontal lobe--basal ganglia structures in HD, with relative sparing of parietal--superior collicular pathways.
Authors:
J R Tian; D S Zee; A G Lasker; S E Folstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  41     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-16     Completed Date:  1991-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  875-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.
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MeSH Terms
Descriptor/Qualifier:
Adult
Electrooculography
Humans
Huntington Disease / physiopathology*
Middle Aged
Photic Stimulation
Reaction Time
Saccades / physiology*
Grant Support
ID/Acronym/Agency:
P01 NS16375/NS/NINDS NIH HHS; P30 EY01765/EY/NEI NIH HHS; R37 EY01849/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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