| SVOC exposure indoors: fresh look at dermal pathways. | |
| | |
MedLine Citation:
|
PMID: 22313149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PRACTICAL IMPLICATIONS: Human exposure to indoor pollutants can occur through dietary and nondietary ingestion, inhalation, and dermal absorption. Many factors influence the relative importance of these pathways, including physical and chemical properties of the pollutants. This paper argues that exposure to indoor semivolatile organic compounds (SVOCs) through the dermal pathway has often been underestimated. Transdermal permeation of SVOCs can be substantially greater than is commonly assumed. Transport of SVOCs from the air to and through the skin is typically not taken into account in exposure assessments. Yet, for certain SVOCs, intake through skin is estimated to be substantially larger than intake through inhalation. Exposure scientists, risk assessors, and public health officials should be mindful of the dermal pathway when estimating exposures to indoor SVOCs. Also, they should recognize that health consequences vary with exposure pathway. For example, an SVOC that enters the blood through the skin does not encounter the same detoxifying enzymes that an ingested SVOC would experience in the stomach, intestines, and liver before it enters the blood. |
| | |
Authors:
|
C J Weschler; W W Nazaroff |
Related Documents
:
|
12766079 - Light-absorbing properties and osmolarity of indocyanine-green depending on concentrati... 23475059 - An intraocular dye solution based on lutein and zeaxanthin in a surrogate internal limi... 10952069 - Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents... 10376459 - Water intubation of the sigmoid colon: water instillation speeds up left-sided colonosc... 23108339 - Modeling colloid deposition on a protein layer adsorbed to iron-oxide-coated sand. 12843639 - Effect of the absorption enhancer saponin on the intrarenal distribution of 5-fluoroura... 9299099 - The surface geometry of vycor 18313969 - Gold-magnetite nanocomposite materials formed via sonochemical methods. 9346569 - Energy status in anoxic rat hepatocytes: effects of isoflurane, solution composition, a... |
Publication Detail:
|
Type: Journal Article; Review Date: 2012-03-02 |
Journal Detail:
|
Title: Indoor air Volume: 22 ISSN: 1600-0668 ISO Abbreviation: Indoor Air Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-11 Completed Date: 2013-02-07 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 9423515 Medline TA: Indoor Air Country: Denmark |
Other Details:
|
Languages: eng Pagination: 356-77 Citation Subset: IM |
Copyright Information:
|
© 2012 John Wiley & Sons A/S. |
Affiliation:
|
Environmental and Occupational Health Sciences Institute, UMDNJ-Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ, USA. weschlch@umdnj.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Air Pollutants
/
analysis*,
pharmacokinetics Air Pollution, Indoor / analysis* Humans Organic Chemicals / analysis*, pharmacokinetics Skin / drug effects*, metabolism* Skin Absorption* |
| Chemical | |
Reg. No./Substance:
|
0/Air Pollutants; 0/Organic Chemicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transvaginal color Doppler sonography predicts ovarian interstitial fibrosis and microvascular injur...
Next Document: Chemical Dynamics Simulations of X<sup>-</sup> + CH<sub>3</sub>Y --> XCH<sub>3</sub> + Y<sup>-</sup>...