| SUVmax reduction improves early prognosis value of interim positron emission tomography scans in diffuse large B-cell lymphoma. | |
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MedLine Citation:
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PMID: 21518924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The prognostic value of interim PET interpreted according to visual criteria is a matter of debate in diffuse large B cell lymphoma (DLBCL). Maximal standardized uptake value reduction (ΔSUVmax) may better predict outcome. To compare the prognostic value of both methods, we analysed PET done at baseline (PET0), after 2 (PET2) and 4 cycles (PET4) in 85 patients with aaIPI 2-3 factors DLBCL enrolled on a prospective multicenter trial. All images were centrally reviewed and interpreted both visually according to the International Harmonization Project (IHP) criteria, and by computing ΔSUVmax between PET0 and PET2 (ΔSUVmaxPET0-2), or PET4 (ΔSUVmaxPET0-4). Optimal cut-off to predict progression or death was 66% for ΔSUVmaxPET0-2 and 70% for ΔSUVmaxPET0-4. Outcomes did not differ significantly whether PET2 and PET4 were visually positive or negative. Inversely, ΔSUVmaxPET0-2 analysis (>66% v ≤66%) identified patients with significantly different 2-year PFS (77% v 57%; p=0.0282) and OS (93% v 60%; p<0.0001). ΔSUVmax PET0-4 analysis (>70% v ≤70%) seemed even more predictive for 2-year PFS (83 v 40%, p<0.0001) and OS (94% v 50%, p<0.0001). ΔSUVmax analysis of sequential interim PET is feasible for high risk DLBCL in a multicenter setting and better predicts outcome than visual analysis based on IHP criteria. The study was registered at http://clinicaltrials.gov as NCT00498043. |
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Authors:
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René-Olivier Casasnovas; Michel Meignan; Alina Berriolo-Riedinger; Stéphane Bardet; Anne Julian; Catherine Thieblemont; Pierre Vera; Serge Bologna; Josette Brière; Jean-Philippe Jais; Corinne Haioun; Bertrand Coiffier; Franck Morschhauser |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-25 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hopital Le Bocage, Dijon, France; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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