Document Detail

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
MedLine Citation:
PMID:  21102611     Owner:  NLM     Status:  MEDLINE    
Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have emerged. Although SUMO-conjugating enzymes can discriminate between SUMO targets, many substrates possess characteristics that facilitate their modification. Other post-translational modifications also regulate SUMO conjugation, suggesting that SUMO signalling is integrated with other signal transduction pathways. A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function of SUMO and substrate conjugation in distinct cellular pathways.
Jaclyn R Gareau; Christopher D Lima
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  11     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-13     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  861-71     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Models, Biological
Models, Molecular
Protein Conformation*
Protein Interaction Domains and Motifs / physiology
SUMO-1 Protein / chemistry,  metabolism
Signal Transduction* / physiology
Small Ubiquitin-Related Modifier Proteins / chemistry,  metabolism*
Substrate Specificity
Sumoylation / physiology*
Grant Support
R01 GM065872/GM/NIGMS NIH HHS; R01 GM065872/GM/NIGMS NIH HHS; R01 GM065872-09/GM/NIGMS NIH HHS; R01 GM065872-10/GM/NIGMS NIH HHS; R01 GM065872-11/GM/NIGMS NIH HHS
Reg. No./Substance:
0/SUMO-1 Protein; 0/Small Ubiquitin-Related Modifier Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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