| The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. | |
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MedLine Citation:
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PMID: 21102611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have emerged. Although SUMO-conjugating enzymes can discriminate between SUMO targets, many substrates possess characteristics that facilitate their modification. Other post-translational modifications also regulate SUMO conjugation, suggesting that SUMO signalling is integrated with other signal transduction pathways. A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function of SUMO and substrate conjugation in distinct cellular pathways. |
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Authors:
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Jaclyn R Gareau; Christopher D Lima |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 11 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-13 Revised Date: 2012-03-27 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 861-71 Citation Subset: IM |
Affiliation:
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Structural Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Humans Models, Biological Models, Molecular Protein Conformation* Protein Interaction Domains and Motifs / physiology SUMO-1 Protein / chemistry, metabolism Signal Transduction* / physiology Small Ubiquitin-Related Modifier Proteins / chemistry, metabolism* Substrate Specificity Sumoylation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM065872/GM/NIGMS NIH HHS; R01 GM065872-09/GM/NIGMS NIH HHS; R01 GM065872-10/GM/NIGMS NIH HHS; R01 GM065872-11/GM/NIGMS NIH HHS; R01 GM065872-12/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/SUMO-1 Protein; 0/Small Ubiquitin-Related Modifier Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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