| SUMO E3 ligase HIGH PLOIDY2 regulates endocycle onset and meristem maintenance in Arabidopsis. | |
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MedLine Citation:
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PMID: 19666737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endoreduplication involves a doubling of chromosomal DNA without corresponding cell division. In plants, many cell types transit from the mitotic cycle to the endoreduplication cycle or endocycle, and this transition is often coupled with the initiation of cell expansion and differentiation. Although a number of cell cycle regulators implicated in endocycle onset have been identified, it is still largely unknown how this transition is developmentally regulated at the whole organ level. Here, we report that a nuclear-localized SUMO E3 ligase, HIGH PLOIDY2 (HPY2), functions as a repressor of endocycle onset in Arabidopsis thaliana meristems. Loss of HPY2 results in a premature transition from the mitotic cycle to the endocycle, leading to severe dwarfism with defective meristems. HPY2 possesses an SP-RING domain characteristic of MMS21-type SUMO E3 ligases, and we show that the conserved residues within this domain are required for the in vivo and in vitro function of HPY2. HPY2 is predominantly expressed in proliferating cells of root meristems and it functions downstream of meristem patterning transcription factors PLETHORA1 (PLT1) and PLT2. These results establish that HPY2-mediated sumoylation modulates the cell cycle progression and meristem development in the PLT-dependent signaling pathway. |
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Authors:
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Takashi Ishida; Sumire Fujiwara; Kenji Miura; Nicola Stacey; Mika Yoshimura; Katja Schneider; Sumiko Adachi; Kazunori Minamisawa; Masaaki Umeda; Keiko Sugimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-07 |
Journal Detail:
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Title: The Plant cell Volume: 21 ISSN: 1040-4651 ISO Abbreviation: Plant Cell Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-11-24 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9208688 Medline TA: Plant Cell Country: United States |
Other Details:
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Languages: eng Pagination: 2284-97 Citation Subset: IM |
Affiliation:
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RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa 230-0045, Japan. |
| Data Bank Information | |
Bank Name/Acc. No.:
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RefSeq/NM_001062862; NP_010896; NP_081022; NP_775956; XP_001713077 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
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cytology*,
growth & development,
metabolism* Arabidopsis Proteins / genetics, metabolism, physiology* Blotting, Western Cell Nucleus / genetics, metabolism Cyclin-Dependent Kinases / genetics, metabolism, physiology Gene Expression Regulation, Plant / genetics, physiology Meristem / cytology*, growth & development, metabolism* Microscopy, Fluorescence Plant Roots / genetics, growth & development, metabolism Transcription Factors / genetics, metabolism, physiology Ubiquitin-Protein Ligases / genetics, metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/CDKA1 protein, Arabidopsis; 0/CDKB1;2 protein, Arabidopsis; 0/CDKb2;2 protein, Arabidopsis; 0/PLT1 protein, Arabidopsis; 0/PLT2 protein, Arabidopsis; 0/Transcription Factors; EC 2.7.1.37/CDKB2;1 protein, Arabidopsis; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 6.3.2.19/Ubiquitin-Protein Ligases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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