Document Detail

SU-8 force sensing pillar arrays for biological measurements.
MedLine Citation:
PMID:  19417913     Owner:  NLM     Status:  MEDLINE    
The generation and sensation of mechanical force plays a role in many dynamic biological processes, including touch sensation. This paper presents a two-axis micro strain gauge force sensor constructed from multiple layers of SU-8 and metal on quartz substrates. The sensor was designed to meet requirements for measuring tactile sensitivity and interaction forces exerted during locomotion by small organisms such as the nematode Caenorhabditis elegans. The device is transparent and compatible with light microscopes, allowing behavioral experiments to be combined with quantitative force measurements. For the first time, we have characterized the scale of interaction forces generated in wild-type C. elegans in probing and responding to their environment during locomotion. The device features sub-microN force resolution from 1 Hz to 1 kHz, >25 microN range, kHz acquisition rates and biocompatibility.
Joseph C Doll; Nahid Harjee; Nathan Klejwa; Ronald Kwon; Sarah M Coulthard; Bryan Petzold; Miriam B Goodman; Beth L Pruitt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-02-27
Journal Detail:
Title:  Lab on a chip     Volume:  9     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-08-28     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1449-54     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena / physiology*
Caenorhabditis elegans / physiology
Computer Simulation
Epoxy Compounds*
Equipment Design
Locomotion / physiology
Microfluidic Analytical Techniques / instrumentation*
Touch / physiology*
Grant Support
EB006745/EB/NIBIB NIH HHS; NS047715/NS/NINDS NIH HHS; R01 EB006745/EB/NIBIB NIH HHS; R01 EB006745-01A1/EB/NIBIB NIH HHS; R01 EB006745-01A1S1/EB/NIBIB NIH HHS; R01 EB006745-02/EB/NIBIB NIH HHS; R01 EB006745-03/EB/NIBIB NIH HHS; R01 NS047715/NS/NINDS NIH HHS; R01 NS047715-05A2/NS/NINDS NIH HHS
Reg. No./Substance:
0/Epoxy Compounds; 0/Polymers; 0/SU-8 compound

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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