Document Detail


STS map of genes and anonymous DNA fragments on human chromosome 18 using a panel of somatic cell hybrids.
MedLine Citation:
PMID:  8449504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Somatic cell hybrids containing different deleted regions of chromosome 18 derived from patients with balanced translocations or terminal deletions were used to create a deletion mapping panel. Twenty-four sequence-tagged sites (STSs) for 17 genes and 7 anonymous polymorphic DNA fragments were identified. These STSs were used to map the 24 loci to 18 defined regions of chromosome 18. Both ERV1, previously mapped to 18q22-q23, and YES1, previously mapped to 18q21.3, were found to map to 18q11.21-pter. Several genes previously mapped to 18q21 were found to be in the order cen-SSAV1-DCC-FECH-GRP-BCL2-PLANH2-tel. The precise mapping of genes to chromosome 18 should help in determining whether these genes may be involved in the etiology of specific chromosomal syndromes associated with chromosome 18. The mapping of the polymorphic loci will assist in the integration of the physical map with the recombination map of chromosome 18.
Authors:
J Overhauser; R Mewar; K Rojas; K Lia; A D Kline; G A Silverman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  15     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-14     Completed Date:  1993-04-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  387-91     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 18*
DNA*
Humans
Hybrid Cells
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Tagged Sites*
Grant Support
ID/Acronym/Agency:
HD28475/HD/NICHD NIH HHS; R29-HG00167/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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