| STOX2 but not STOX1 is differentially expressed in decidua from pre-eclamptic women: data from the Second Nord-Trondelag Health Study. | |
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MedLine Citation:
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PMID: 20643876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variation in the Storkhead box-1 (STOX1) gene has previously been associated with pre-eclampsia. In this study, we assess candidate single nucleotide polymorphisms (SNPs) in STOX1 in an independent population cohort of pre-eclamptic (n = 1.139) and non-pre-eclamptic (n = 2.269) women (the HUNT2 study). We also compare gene expression levels of STOX1 and its paralogue, Storkhead box-2 (STOX2) in decidual tissue from pregnancies complicated by pre-eclampsia and/or fetal growth restriction (FGR) (n = 40) to expression levels in decidual tissue from uncomplicated pregnancies (n = 59). We cannot confirm association of the candidate SNPs to pre-eclampsia (P > 0.05). For STOX1, no differential gene expression was observed in any of the case groups, whereas STOX2 showed significantly lower expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls (P = 0.01). We further report a strong correlation between transcriptional alterations reported previously in choriocarcinoma cells over expressing STOX1A and alterations observed in decidual tissue of pre-eclamptic women with FGR. |
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Authors:
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M H Fenstad; M P Johnson; M Løset; S B Mundal; L T Roten; I P Eide; L Bjørge; R K Sande; A K Johansson; T D Dyer; S Forsmo; J Blangero; E K Moses; R Austgulen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-19 |
Journal Detail:
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Title: Molecular human reproduction Volume: 16 ISSN: 1460-2407 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-03-16 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 960-8 Citation Subset: IM |
Affiliation:
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Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7006, Norway. mona.n.fenstad@ntnu.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carrier Proteins / genetics*, metabolism, physiology Cohort Studies Decidua / metabolism* Female Fetal Growth Retardation / genetics, metabolism Gene Expression Genotype Humans Polymorphism, Single Nucleotide Pre-Eclampsia / genetics, metabolism* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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HD049847/HD/NICHD NIH HHS; MH059490/MH/NIMH NIH HHS; RR013556/RR/NCRR NIH HHS; RR017515/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/STOX1 protein, human |
| Comments/Corrections | |
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