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STK39 is an independent risk factor for male hypertension in Han Chinese.
MedLine Citation:
PMID:  20889219     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: STK39 interacts with OXSR1 and phosphorylates the sodium-chloride co-transporter (SLC12A3), which plays a critical role in regulating the salt/water balance and blood pressure. Here we tested whether STK39, OXSR1, and SLC12A3 genetically contribute to hypertension in the Han Chinese population and how the SNP to SNP or SNP to other risk factors interacts in the pathogenesis of hypertension.
METHODS AND RESULTS: Eleven tagging SNPs from STK39, OXSR1, and SLC12A3 were selected and first genotyped in 1210 hypertensive and healthy individuals by sequencing. Two SNPs of STK39, rs6433027 and rs3754777, were found to be associated with hypertension in males (P=0.008-0.024). All other SNPs were not associated with hypertension in either gender. The association of rs6433027 and rs3754777 with male hypertension was validated by genotyping another 4598 hypertensive and healthy individuals. The odds ratios (95% confidence interval, P value) in males were 1.269 (1.13-1.43; P=0.0001) and 1.231 (1.078-1.41; P=0.004) of rs6433027 and rs3754777, respectively. The allele T of rs6433027 presented a strong epistatic effect on the allele A of rs3754777 in hypertensive trait. The minor allele frequencies of two SNPs were not stratified by age, BMI, or diabetes, the three major risk factors for hypertension.
CONCLUSION: Our results suggest that STK39 is an independent risk factor for hypertension in men and that its intragenic SNPs can interact and function in the control of blood pressure.
Li-Yan Chen; Wei-Hua Zhao; Wen Tian; Jian Guo; Feng Jiang; Li-Juan Jin; Ying-Xian Sun; Kai-Ming Chen; Li-Li An; Guo-Dong Li; Qing Li; Yang Li; Chong Wu; Ling Zhao; Wen-Jing Wang; Gu-Yan Zheng; Bing Li; Xue-Qi Li; Jian Hu; Xiao-Li Tian
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Publication Detail:
Type:  Journal Article     Date:  2010-10-02
Journal Detail:
Title:  International journal of cardiology     Volume:  154     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang, China.
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