Document Detail


STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals.
MedLine Citation:
PMID:  19473984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ca(2+) signals controlling a vast array of cell functions involve both Ca(2+) store release and external Ca(2+) entry. These two events are coordinated through a dynamic intermembrane coupling between two distinct membrane proteins, STIM and Orai. STIM proteins are endoplasmic reticulum (ER) luminal Ca(2+) sensors that undergo a profound redistribution into discrete junctional ER domains closely juxtaposed with the plasma membrane (PM). Orai proteins are PM Ca(2+) channels that migrate and become tethered by STIM within the ER-PM junctions, where they mediate exceedingly selective Ca(2+) entry. We describe a new understanding of the nature of the proteins and how they function to mediate this remarkable intermembrane signaling process controlling Ca(2+) signals.
Authors:
Xiaoxiang Deng; Youjun Wang; Yandong Zhou; Jonathan Soboloff; Donald L Gill
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-05-27
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  284     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-10-06     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22501-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channels / metabolism,  physiology*
Calcium Signaling / physiology*
Humans
Membrane Proteins / metabolism,  physiology*
Models, Biological
Neoplasm Proteins / metabolism,  physiology
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/Membrane Proteins; 0/Neoplasm Proteins; 0/ORAI1 protein, human; 0/STIM1 protein, human
Comments/Corrections

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