Document Detail

STATs shape the active enhancer landscape of T cell populations.
MedLine Citation:
PMID:  23178119     Owner:  NLM     Status:  MEDLINE    
Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. Although enhancers are recognized as key elements that regulate selective gene expression, the interplay between signaling pathways and actively used enhancer elements is not clear. Here, we use CD4(+) T cells as a model of differentiation, mapping the activity of cell-type-specific enhancer elements in T helper 1 (Th1) and Th2 cells. Our data establish that STAT proteins have a major impact on the activation of lineage-specific enhancers and the suppression of enhancers associated with alternative cell fates. Transcriptome analysis further supports a functional role for enhancers regulated by STATs. Importantly, expression of lineage-defining master regulators in STAT-deficient cells fails to fully recover the chromatin signature of STAT-dependent enhancers. Thus, these findings point to a critical role of STATs as environmental sensors in dynamically molding the specialized enhancer architecture of differentiating cells.
Golnaz Vahedi; Hayato Takahashi; Shingo Nakayamada; Hong-Wei Sun; Vittorio Sartorelli; Yuka Kanno; John J O'Shea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  151     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-01-24     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  981-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
CD4-Positive T-Lymphocytes / cytology*,  metabolism
Cell Differentiation*
Cytokines / metabolism
Enhancer Elements, Genetic*
GATA3 Transcription Factor / metabolism
Genes, Essential
Mice, Inbred C57BL
STAT Transcription Factors / genetics,  metabolism*
T-Box Domain Proteins / metabolism
Th1 Cells / cytology*
Th2 Cells / cytology*
p300-CBP Transcription Factors / metabolism
Grant Support
Z01 AR041159-01/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Cytokines; 0/GATA3 Transcription Factor; 0/Gata3 protein, mouse; 0/STAT Transcription Factors; 0/T-Box Domain Proteins; 0/T-box transcription factor TBX21; EC Transcription Factors
Comment In:
Cell. 2012 Nov 21;151(5):929-31   [PMID:  23178114 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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