Document Detail


STAT6-dependent regulation of Th9 development.
MedLine Citation:
PMID:  22180613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Th cell effector subsets develop in response to specific cytokine environments. The development of a particular cytokine-secreting pattern requires an integration of signals that may promote the development of opposing pathways. A recent example of this paradigm is the IL-9-secreting Th9 cell that develops in response to TGF-β and IL-4, cytokines that, in isolation, promote the development of inducible regulatory T cells and Th2 cells, respectively. To determine how the balance of these factors results in priming for IL-9 secretion, we examined the effects of each pathway on transcription factors that regulate Th cell differentiation. We demonstrated that TGF-β induces the PU.1-encoding Sfpi1 locus and that this is independent of IL-4-induced STAT6 activation. IL-4-activated STAT6 is required for repressing the expression of T-bet and Foxp3 in Th9 cells, transcription factors that inhibit IL-9 production, and STAT6 is required for the induction of IRF4, which promotes Th9 development. These data established a transcription factor network that regulates IL-9 and demonstrated how combinations of cytokine signals generate cytokine-secreting potential by altering the expression of a panel of transcription factors.
Authors:
Ritobrata Goswami; Rukhsana Jabeen; Ryoji Yagi; Duy Pham; Jinfang Zhu; Shreevrat Goenka; Mark H Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-12-16
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  188     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  2012-06-11     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-75     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cytokines
Gene Regulatory Networks
Interferon Regulatory Factors / genetics
Interleukin-4 / immunology
Interleukin-9 / secretion*
Mice
Proto-Oncogene Proteins / genetics
STAT6 Transcription Factor / physiology*
Signal Transduction / immunology
T-Lymphocytes, Helper-Inducer / cytology,  secretion*
Trans-Activators / genetics
Transcriptional Activation
Grant Support
ID/Acronym/Agency:
AI057459/AI/NIAID NIH HHS; HL093105/HL/NHLBI NIH HHS; R01 AI057459/AI/NIAID NIH HHS; R01 AI057459-06/AI/NIAID NIH HHS; R01 AI057459-07/AI/NIAID NIH HHS; ZIA AI001169-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interferon Regulatory Factors; 0/Interleukin-9; 0/Proto-Oncogene Proteins; 0/STAT6 Transcription Factor; 0/Stat6 protein, mouse; 0/Trans-Activators; 0/interferon regulatory factor-4; 0/proto-oncogene protein Spi-1; 207137-56-2/Interleukin-4
Comments/Corrections

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