| STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. | |
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MedLine Citation:
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PMID: 9162009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine. STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation. Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor. |
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Authors:
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L M Pfeffer; J E Mullersman; S R Pfeffer; A Murti; W Shi; C H Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 276 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-16 Completed Date: 1997-06-16 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1418-20 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase Acute-Phase Proteins / genetics* Amino Acid Sequence Androstadienes / pharmacology Animals Binding Sites COS Cells Cell Line Cloning, Molecular Conserved Sequence DNA-Binding Proteins / genetics, metabolism* Enzyme Inhibitors / pharmacology Membrane Proteins Molecular Sequence Data Phosphorylation Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors, genetics, metabolism* Point Mutation Protein Binding Receptor, Interferon alpha-beta Receptors, Interferon / metabolism* Recombinant Fusion Proteins / genetics, metabolism STAT3 Transcription Factor Signal Transduction Trans-Activators / genetics, metabolism* Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Androstadienes; 0/DNA-Binding Proteins; 0/Enzyme Inhibitors; 0/Membrane Proteins; 0/Receptors, Interferon; 0/Recombinant Fusion Proteins; 0/STAT3 Transcription Factor; 0/Trans-Activators; 156986-95-7/Receptor, Interferon alpha-beta; 19545-26-7/wortmannin; 55520-40-6/Tyrosine; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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